TFAP4
transcription factor AP-4 | AP-4, bHLHc41

Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed 2123466]).[supplied by OMIM, Jul 2009]

Member of: DE-6
Biological processes 45 terms
DNA binding (GO:0003677)DNA damage response, signal transduction by p53 class mediator (GO:0030330)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)E-box binding (GO:0070888)E-box binding (GO:0070888)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)cellular response to dexamethasone stimulus (GO:0071549)chromatin (GO:0000785)histone deacetylase binding (GO:0042826)histone deacetylase binding (GO:0042826)host-mediated activation of viral transcription (GO:0043923)host-mediated suppression of viral transcription (GO:0043922)host-mediated suppression of viral transcription (GO:0043922)negative regulation of DNA binding (GO:0043392)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of cell population proliferation (GO:0008285)negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)negative regulation of gene expression (GO:0010629)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of apoptotic process (GO:0043065)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein dimerization activity (GO:0046983)protein homodimerization activity (GO:0042803)protein-containing complex assembly (GO:0065003)protein-containing complex assembly (GO:0065003)regulation of mitotic cell cycle phase transition (GO:1901990)regulation of transcription by RNA polymerase II (GO:0006357)sequence-specific DNA binding (GO:0043565)sequence-specific double-stranded DNA binding (GO:1990837)transcription cis-regulatory region binding (GO:0000976)transcription cis-regulatory region binding (GO:0000976)transcription repressor complex (GO:0017053)transcription repressor complex (GO:0017053)
Expression (TPM)
TFAP4 — as a Regulated Gene

TFs regulating TFAP4 0 TFs

Transcription factors with Perturb-seq knockdown data for TFAP4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TFAP4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to TFAP4

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TFAP4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr16:4,115,028–4,117,244 156.3 kb Distal (>10kb) Multiome 659
chr16:4,183,149–4,184,737 88.9 kb Distal (>10kb) Multiome 944
chr16:4,244,460–4,244,980 28.3 kb Distal (>10kb) Multiome 290
chr16:4,253,312–4,254,436 18.9 kb Distal (>10kb) Multiome 960
chr16:4,263,483–4,264,402 9.1 kb Proximal (<10kb) Multiome 258
chr16:4,271,070–4,274,312 1.1 kb Proximal (<10kb) Multiome 1130
chr16:4,293,681–4,294,322 21.1 kb Distal (>10kb) Multiome 385
chr16:4,307,236–4,308,275 34.9 kb Distal (>10kb) Multiome 635
chr16:4,309,629–4,310,195 37.1 kb Distal (>10kb) Multiome 351
chr16:4,315,041–4,316,747 42.9 kb Distal (>10kb) Multiome 520
chr16:4,327,446–4,328,634 55.4 kb Distal (>10kb) Multiome 495
chr16:4,350,579–4,351,773 78.5 kb Distal (>10kb) Multiome 674
chr16:4,371,473–4,372,791 98.9 kb Distal (>10kb) Multiome 617
chr16:4,402,485–4,403,104 129.9 kb Distal (>10kb) Multiome 450
chr16:4,415,818–4,417,201 143.8 kb Distal (>10kb) Multiome 681
chr16:4,425,392–4,426,322 152.8 kb Distal (>10kb) Multiome 881
chr16:4,474,111–4,474,929 201.7 kb Distal (>10kb) Multiome 626
chr16:4,476,027–4,477,237 203.5 kb Distal (>10kb) Multiome 841
chr16:4,537,639–4,538,998 265.8 kb Distal (>10kb) Multiome 1087

Genome Browser

Genomic view of the TFAP4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr16:4,105,028 – 4,548,998
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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