The protein encoded by this gene is a nuclear hormone receptor and transcriptional regulator. The encoded protein acts as a homodimer and binds to 5'-AGGTCA-3' repeats. Defects in this gene are a cause of Bosch-Boonstra optic atrophy syndrome (BBOAS). [provided by RefSeq, Apr 2014]
Transcription factors with Perturb-seq knockdown data for NR2F1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NR2F1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NR2F1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:93,577,092–93,577,226 | 7.8 kb | Proximal (<10kb) | 39 | |
| chr5:93,578,889–93,582,135 | 2.9 kb | Proximal (<10kb) | 840 | |
| chr5:93,582,706–93,583,399 | 1.6 kb | Proximal (<10kb) | 756 | |
| chr5:93,583,889–93,585,761 | at TSS | At TSS | 473 | |
| chr5:93,587,646–93,588,920 | 2.6 kb | Proximal (<10kb) | 224 | |
| chr5:93,593,487–93,594,028 | 8.5 kb | Proximal (<10kb) | 57 | |
| chr5:93,594,776–93,596,142 | 9.8 kb | Proximal (<10kb) | 151 |
Genomic view of the NR2F1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.