This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SMC3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SMC3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SMC3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:110,304,286–110,305,616 | 262.7 kb | Distal (>10kb) Multiome HiCAR | 717 | |
| chr10:110,324,327–110,325,094 | 243.0 kb | Distal (>10kb) Multiome HiCAR | 220 | |
| chr10:110,483,548–110,484,272 | 83.9 kb | Distal (>10kb) Multiome | 273 | |
| chr10:110,493,733–110,494,428 | 73.6 kb | Distal (>10kb) Multiome | 112 | |
| chr10:110,497,303–110,499,967 | 69.8 kb | Distal (>10kb) Multiome | 772 | |
| chr10:110,529,265–110,530,944 | 37.4 kb | Distal (>10kb) Multiome | 543 | |
| chr10:110,566,581–110,568,626 | 187 bp | At TSS Multiome | 1050 | |
| chr10:110,610,178–110,611,174 | 42.9 kb | Distal (>10kb) Multiome | 383 | |
| chr10:110,643,641–110,644,831 | 76.6 kb | Distal (>10kb) Multiome | 427 | |
| chr10:110,671,928–110,672,573 | 104.6 kb | Distal (>10kb) Multiome | 567 | |
| chr10:110,701,236–110,702,762 | 134.2 kb | Distal (>10kb) Multiome | 253 | |
| chr10:110,833,606–110,834,169 | 266.1 kb | Distal (>10kb) Multiome | 160 | |
| chr10:110,857,173–110,858,770 | 289.9 kb | Distal (>10kb) Multiome | 690 |
Genomic view of the SMC3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.