TFAP2C

transcription factor AP-2 gamma | AP2-GAMMA, ERF1, TFAP2G, hAP-2g

The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. [provided by RefSeq, Jul 2008]

Biological processes 34 terms

DNA binding (GO:0003677)DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)cell-cell signaling (GO:0007267)chromatin (GO:0000785)cytosol (GO:0005829)inner cell mass cell differentiation (GO:0001826)male gonad development (GO:0008584)morula formation (GO:0140001)morula formation (GO:0140001)negative regulation of gene expression, epigenetic (GO:0045814)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of cell population proliferation (GO:0042127)regulation of transcription by RNA polymerase II (GO:0006357)sequence-specific double-stranded DNA binding (GO:1990837)

Expression (TPM)

TFs regulating TFAP2C 0 TFs

Transcription factors with Perturb-seq knockdown data for TFAP2C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TFAP2C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to TFAP2C

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TFAP2C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr20:56,358,373–56,359,678	270.4 kb	Distal (>10kb) Multiome	612
chr20:56,391,539–56,393,046	236.9 kb	Distal (>10kb) Multiome	1080
chr20:56,468,222–56,468,931	160.7 kb	Distal (>10kb) Multiome	887
chr20:56,624,898–56,625,604	4.2 kb	Proximal (<10kb) Multiome	210
chr20:56,626,234–56,627,000	2.3 kb	Proximal (<10kb)	168
chr20:56,628,380–56,631,136	1.1 kb	Proximal (<10kb) Multiome	551
chr20:56,631,439–56,631,930	2.1 kb	Proximal (<10kb)	111
chr20:56,632,340–56,632,526	3.0 kb	Proximal (<10kb)	23
chr20:56,632,796–56,633,063	3.5 kb	Proximal (<10kb)	12
chr20:56,637,388–56,637,627	8.1 kb	Proximal (<10kb)	31
chr20:56,690,044–56,691,001	61.3 kb	Distal (>10kb) Multiome	191
chr20:56,736,238–56,736,823	107.2 kb	Distal (>10kb) Multiome HiCAR	206
chr20:56,748,308–56,749,036	119.4 kb	Distal (>10kb) Multiome	90
chr20:56,750,435–56,750,924	121.3 kb	Distal (>10kb) Multiome	88
chr20:56,909,645–56,910,383	280.7 kb	Distal (>10kb) Multiome HiCAR	68
chr20:56,924,946–56,925,893	296.1 kb	Distal (>10kb) Multiome HiCAR	435
chr20:57,002,615–57,003,823	374.0 kb	Distal (>10kb) Multiome HiCAR	200

Genome Browser

Genomic view of the TFAP2C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.