ZNF148

zinc finger protein 148 | BERF-1, BFCOL1, HT-BETA, ZBP-89, ZFP148, pHZ-52

The protein encoded by this gene is a member of the Kruppel family of zinc finger DNA binding proteins. The encoded protein activates transcription of the T-cell receptor and intestinal alkaline phosphatase genes but represses transcription of the ornithine decarboxylase, vimentin, gastrin, stomelysin, and enolase genes. Increased expression of this gene results in decreased patient survival rates from colorectal cancer, while mutations in this gene have been associated with global developmental delay, hypoplastic corpus callosum, and dysmorphic facies. [provided by RefSeq, Feb 2017]

Member of: DE-3 DE-3.24 Developmental clusters: GC7

Biological processes 17 terms

DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)cellular defense response (GO:0006968)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of gene expression (GO:0010629)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleoplasm (GO:0005654)nucleus (GO:0005634)protein binding (GO:0005515)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)sequence-specific DNA binding (GO:0043565)substantia nigra development (GO:0021762)transcription cis-regulatory region binding (GO:0000976)

Expression (TPM)

TFs regulating ZNF148 0 TFs

Transcription factors with Perturb-seq knockdown data for ZNF148. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF148 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ZNF148

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF148, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr3:125,120,569–125,121,347	254.3 kb	Distal (>10kb) Multiome	178
chr3:125,141,761–125,142,375	233.2 kb	Distal (>10kb) Multiome	228
chr3:125,155,911–125,156,374	219.2 kb	Distal (>10kb) Multiome	134
chr3:125,211,780–125,213,160	162.9 kb	Distal (>10kb) Multiome	258
chr3:125,357,135–125,357,657	17.9 kb	Distal (>10kb) Multiome	492
chr3:125,374,544–125,375,878	19 bp	At TSS Multiome	864
chr3:125,519,541–125,520,583	144.9 kb	Distal (>10kb) Multiome	696
chr3:125,595,065–125,596,211	220.3 kb	Distal (>10kb) Multiome	735

Genome Browser

Genomic view of the ZNF148 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.