PLAGL2

PLAG1 like zinc finger 2 | ZNF900

Pleiomorphic adenoma gene-like 2 is a zinc-finger protein that recognizes DNA and/or RNA. [provided by RefSeq, Jul 2008]

Member of: DE-6

Biological processes 12 terms

DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)regulation of transcription by RNA polymerase II (GO:0006357)sequence-specific DNA binding (GO:0043565)sequence-specific DNA binding (GO:0043565)sequence-specific DNA binding (GO:0043565)

Expression (TPM)

TFs regulating PLAGL2 0 TFs

Transcription factors with Perturb-seq knockdown data for PLAGL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLAGL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PLAGL2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLAGL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr20:31,951,523–31,952,606	255.7 kb	Distal (>10kb) Multiome	879
chr20:31,967,880–31,968,893	239.3 kb	Distal (>10kb) Multiome	1059
chr20:31,972,125–31,972,938	235.3 kb	Distal (>10kb) Multiome	252
chr20:32,017,795–32,019,711	189.4 kb	Distal (>10kb) Multiome	611
chr20:32,031,048–32,031,781	176.2 kb	Distal (>10kb) Multiome	627
chr20:32,109,321–32,110,237	98.0 kb	Distal (>10kb) Multiome	1073
chr20:32,189,679–32,190,832	17.4 kb	Distal (>10kb) Multiome	290
chr20:32,207,261–32,208,118	42 bp	At TSS Multiome	903
chr20:32,277,439–32,278,095	69.9 kb	Distal (>10kb) Multiome	804
chr20:32,357,509–32,359,534	151.6 kb	Distal (>10kb) Multiome	1138
chr20:32,456,960–32,457,933	249.7 kb	Distal (>10kb) Multiome	407
chr20:32,482,216–32,484,943	276.0 kb	Distal (>10kb) Multiome	976

Genome Browser

Genomic view of the PLAGL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.