This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Many members of the forkhead box gene family, including members of subfamily P, have roles in mammalian oncogenesis. This gene may play a role in the development of tumors of the kidney and larynx. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FOXP4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FOXP4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FOXP4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:41,318,625–41,319,323 | 227.4 kb | Distal (>10kb) Multiome | 629 | |
| chr6:41,373,601–41,374,643 | 172.1 kb | Distal (>10kb) Multiome | 200 | |
| chr6:41,406,787–41,407,231 | 139.3 kb | Distal (>10kb) Multiome | 115 | |
| chr6:41,408,576–41,409,789 | 137.1 kb | Distal (>10kb) Multiome | 127 | |
| chr6:41,427,536–41,428,491 | 118.4 kb | Distal (>10kb) Multiome HiCAR | 477 | |
| chr6:41,442,795–41,443,887 | 103.2 kb | Distal (>10kb) Multiome | 389 | |
| chr6:41,504,922–41,505,512 | 41.0 kb | Distal (>10kb) Multiome | 231 | |
| chr6:41,545,684–41,547,717 | 116 bp | At TSS Multiome | 837 | |
| chr6:41,555,423–41,556,068 | 9.0 kb | Proximal (<10kb) | 188 | |
| chr6:41,560,291–41,561,295 | 14.4 kb | Distal (>10kb) Multiome | 321 | |
| chr6:41,577,904–41,579,491 | 32.3 kb | Distal (>10kb) Multiome | 740 | |
| chr6:41,638,107–41,639,488 | 92.1 kb | Distal (>10kb) Multiome | 240 | |
| chr6:41,683,281–41,684,037 | 137.4 kb | Distal (>10kb) Multiome | 492 | |
| chr6:41,733,652–41,736,107 | 187.9 kb | Distal (>10kb) Multiome | 908 | |
| chr6:41,779,509–41,781,116 | 233.7 kb | Distal (>10kb) Multiome | 857 | |
| chr6:41,786,100–41,787,779 | 240.1 kb | Distal (>10kb) Multiome | 1106 |
Genomic view of the FOXP4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.