FOXK2

forkhead box K2 | ILF, ILF1

The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements. [provided by RefSeq, Jul 2008]

Member of: DE-2 DE-2.1

Biological processes 44 terms

DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)canonical glycolysis (GO:0061621)chromatin (GO:0000785)cytoplasm (GO:0005737)intracellular glucose homeostasis (GO:0001678)intracellular glucose homeostasis (GO:0001678)magnesium ion binding (GO:0000287)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of autophagy (GO:0010507)negative regulation of autophagy (GO:0010507)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of DNA-templated transcription (GO:0006355)regulation of glucose metabolic process (GO:0010906)regulation of glucose metabolic process (GO:0010906)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)response to starvation (GO:0042594)response to starvation (GO:0042594)sequence-specific DNA binding (GO:0043565)sequence-specific DNA binding (GO:0043565)transcription cis-regulatory region binding (GO:0000976)transcription cis-regulatory region binding (GO:0000976)

Expression (TPM)

TFs regulating FOXK2 0 TFs

Transcription factors with Perturb-seq knockdown data for FOXK2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FOXK2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to FOXK2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FOXK2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:82,228,266–82,232,536	290.7 kb	Distal (>10kb) Multiome	1048
chr17:82,272,608–82,274,062	246.0 kb	Distal (>10kb) Multiome	943
chr17:82,278,488–82,279,226	240.8 kb	Distal (>10kb) Multiome	229
chr17:82,292,400–82,293,256	226.8 kb	Distal (>10kb) Multiome	944
chr17:82,414,581–82,415,044	104.9 kb	Distal (>10kb) Multiome	799
chr17:82,417,993–82,419,018	101.2 kb	Distal (>10kb) Multiome	844
chr17:82,450,369–82,451,002	68.9 kb	Distal (>10kb) Multiome	837
chr17:82,458,067–82,459,318	61.2 kb	Distal (>10kb) Multiome	1054
chr17:82,494,122–82,495,128	25.0 kb	Distal (>10kb) Multiome	1010
chr17:82,496,968–82,497,781	22.4 kb	Distal (>10kb) Multiome	613
chr17:82,519,154–82,520,226	124 bp	At TSS Multiome	869
chr17:82,647,682–82,648,684	128.9 kb	Distal (>10kb) Multiome	874
chr17:82,697,983–82,699,271	179.1 kb	Distal (>10kb) Multiome	623
chr17:82,715,983–82,717,178	196.9 kb	Distal (>10kb) Multiome	744
chr17:82,735,174–82,736,034	215.8 kb	Distal (>10kb) Multiome	649
chr17:82,751,094–82,752,780	232.0 kb	Distal (>10kb) Multiome	987
chr17:82,754,710–82,755,244	235.2 kb	Distal (>10kb) Multiome	188

Genome Browser

Genomic view of the FOXK2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.