BACH1

BTB domain and CNC homolog 1 | BACH-1, BTBD24

This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, May 2009]

Member of: DE-3 DE-3.47

Biological processes 34 terms

DNA binding (GO:0003677)DNA repair (GO:0006281)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)chromatin (GO:0000785)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)heme binding (GO:0020037)ligand-modulated transcription factor activity (GO:0098531)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)

Expression (TPM)

TFs regulating BACH1 0 TFs

Transcription factors with Perturb-seq knockdown data for BACH1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BACH1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to BACH1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BACH1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr21:29,002,426–29,003,155	296.1 kb	Distal (>10kb) Multiome	924
chr21:29,018,921–29,019,505	279.6 kb	Distal (>10kb) Multiome	771
chr21:29,024,275–29,025,379	274.1 kb	Distal (>10kb) Multiome	850
chr21:29,072,977–29,074,186	225.2 kb	Distal (>10kb) Multiome	1002
chr21:29,298,181–29,300,594	12 bp	At TSS Multiome	929
chr21:29,302,477–29,302,632	3.6 kb	Proximal (<10kb)	58
chr21:29,430,090–29,431,525	131.7 kb	Distal (>10kb) Multiome	177

Genome Browser

Genomic view of the BACH1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.