This locus encodes a member of the fork-head transcription factor family. The encoded protein, which functions as a transcriptional repressor, is highly expressed in neural tissues during brain development. Mutations at this locus have been associated with Rett syndrome and a diverse spectrum of neurodevelopmental disorders defined as part of the FOXG1 syndrome. This gene is disregulated in many types of cancer and is the target of multiple microRNAs that regulate the proliferation of tumor cells. [provided by RefSeq, Jul 2020]
Transcription factors with Perturb-seq knockdown data for FOXG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FOXG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FOXG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:28,756,981–28,757,394 | 9.4 kb | Proximal (<10kb) | 232 | |
| chr14:28,758,498–28,760,371 | 6.4 kb | Proximal (<10kb) | 232 | |
| chr14:28,762,047–28,762,574 | 4.2 kb | Proximal (<10kb) | 41 | |
| chr14:28,764,235–28,764,685 | 2.1 kb | Proximal (<10kb) | 155 | |
| chr14:28,765,678–28,768,680 | at TSS | At TSS | 601 | |
| chr14:28,773,909–28,775,119 | 7.1 kb | Proximal (<10kb) | 225 |
Genomic view of the FOXG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.