JUN

JUN

Jun proto-oncogene, AP-1 transcription factor subunit | AP-1, c-Jun

This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]

Developmental clusters: GC7

Biological processes 75 terms

DNA binding (GO:0003677)DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)GTPase activator activity (GO:0005096)JNK cascade (GO:0007254)JNK cascade (GO:0007254)R-SMAD binding (GO:0070412)RNA binding (GO:0003723)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)SMAD protein signal transduction (GO:0060395)cAMP response element binding (GO:0035497)cellular response to anisomycin (GO:0072740)chromatin (GO:0000785)chromatin (GO:0000785)chromatin binding (GO:0003682)double-stranded DNA binding (GO:0003690)enzyme binding (GO:0019899)euchromatin (GO:0000791)general transcription initiation factor binding (GO:0140296)host-mediated activation of viral transcription (GO:0043923)host-mediated suppression of viral transcription (GO:0043922)identical protein binding (GO:0042802)integrated stress response signaling (GO:0140467)negative regulation of DNA binding (GO:0043392)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)nuclear chromosome (GO:0000228)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of DNA-templated transcription initiation (GO:2000144)positive regulation of miRNA transcription (GO:1902895)positive regulation of miRNA transcription (GO:1902895)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of vascular associated smooth muscle cell proliferation (GO:1904707)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of cell cycle (GO:0051726)regulation of cell population proliferation (GO:0042127)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)release from viral latency (GO:0019046)response to endoplasmic reticulum stress (GO:0034976)response to steroid hormone (GO:0048545)sequence-specific double-stranded DNA binding (GO:1990837)transcription cis-regulatory region binding (GO:0000976)transcription cis-regulatory region binding (GO:0000976)transcription factor AP-1 complex (GO:0035976)transcription factor AP-1 complex (GO:0035976)transcription factor AP-1 complex (GO:0035976)transcription regulator complex (GO:0005667)transcription regulator complex (GO:0005667)transcription repressor complex (GO:0017053)transforming growth factor beta receptor signaling pathway (GO:0007179)transforming growth factor beta1 production (GO:0032905)ubiquitin protein ligase binding (GO:0031625)ubiquitin-like protein ligase binding (GO:0044389)

Expression (TPM)

TFs regulating JUN 0 TFs

Transcription factors with Perturb-seq knockdown data for JUN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = JUN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to JUN

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of JUN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility	Element	Dist. to TSS	Link type	TFs
	chr1:58,545,902–58,547,165	237.3 kb	Distal (>10kb) Multiome	808
	chr1:58,576,513–58,577,828	206.8 kb	Distal (>10kb) Multiome	406
	chr1:58,699,577–58,700,464	84.0 kb	Distal (>10kb) Multiome	702
	chr1:58,704,094–58,705,219	79.2 kb	Distal (>10kb) Multiome	154
	chr1:58,781,568–58,782,045	2.0 kb	Proximal (<10kb)	408
	chr1:58,782,095–58,785,778	127 bp	At TSS Multiome	1186
	chr1:58,814,035–58,816,778	32.4 kb	Distal (>10kb) Multiome	966
	chr1:58,853,148–58,854,080	69.6 kb	Distal (>10kb) Multiome	53
	chr1:58,884,762–58,885,830	101.4 kb	Distal (>10kb) Multiome HiCAR	725
	chr1:58,896,308–58,897,070	112.6 kb	Distal (>10kb) Multiome	425
	chr1:58,903,394–58,904,485	119.9 kb	Distal (>10kb) Multiome HiCAR	782
	chr1:59,077,777–59,078,789	294.2 kb	Distal (>10kb) Multiome HiCAR	361
	chr1:59,296,207–59,297,834	512.8 kb	Distal (>10kb) Multiome HiCAR	874
	chr1:59,769,240–59,769,882	985.5 kb	Distal (>10kb) Multiome HiCAR	103

Genome Browser

Genomic view of the JUN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.