This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2010]
Transcription factors with Perturb-seq knockdown data for RBBP5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBBP5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBBP5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:204,828,302–204,828,945 | 293.3 kb | Distal (>10kb) Multiome | 287 | |
| chr1:204,923,251–204,924,645 | 197.6 kb | Distal (>10kb) Multiome | 297 | |
| chr1:204,927,214–204,930,121 | 192.7 kb | Distal (>10kb) Multiome | 387 | |
| chr1:204,991,288–204,991,881 | 130.4 kb | Distal (>10kb) Multiome | 157 | |
| chr1:205,121,687–205,122,681 | 216 bp | At TSS Multiome | 1123 | |
| chr1:205,210,792–205,212,030 | 89.6 kb | Distal (>10kb) Multiome | 1103 | |
| chr1:205,227,416–205,228,381 | 105.9 kb | Distal (>10kb) Multiome | 495 | |
| chr1:205,229,263–205,229,745 | 107.7 kb | Distal (>10kb) Multiome | 331 | |
| chr1:205,300,603–205,302,127 | 179.5 kb | Distal (>10kb) Multiome | 660 | |
| chr1:205,313,308–205,314,407 | 192.0 kb | Distal (>10kb) Multiome | 327 | |
| chr1:205,321,242–205,322,079 | 199.8 kb | Distal (>10kb) Multiome | 705 | |
| chr1:205,343,395–205,344,420 | 222.0 kb | Distal (>10kb) Multiome | 395 |
Genomic view of the RBBP5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.