The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Transcription factors with Perturb-seq knockdown data for MAF. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAF upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAF, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:78,243,715–78,244,828 | 1356.1 kb | Distal (>10kb) Multiome HiCAR | 121 | |
| chr16:79,298,072–79,299,813 | 302.4 kb | Distal (>10kb) Multiome HiCAR | 199 | |
| chr16:79,412,299–79,413,225 | 187.9 kb | Distal (>10kb) Multiome | 260 | |
| chr16:79,589,839–79,590,036 | 9.9 kb | Proximal (<10kb) | 68 | |
| chr16:79,598,623–79,601,940 | 1.8 kb | Proximal (<10kb) Multiome | 814 | |
| chr16:79,602,059–79,602,669 | 2.2 kb | Proximal (<10kb) | 295 | |
| chr16:79,654,553–79,655,141 | 54.1 kb | Distal (>10kb) Multiome | 110 | |
| chr16:79,723,489–79,724,240 | 123.2 kb | Distal (>10kb) Multiome | 180 | |
| chr16:79,770,176–79,771,048 | 169.9 kb | Distal (>10kb) Multiome | 487 |
Genomic view of the MAF locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.