The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.[provided by RefSeq, Jun 2010]
Transcription factors with Perturb-seq knockdown data for BCOR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BCOR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BCOR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:39,821,174–39,821,699 | 355.9 kb | Distal (>10kb) Multiome | 147 | |
| chrX:40,008,825–40,009,356 | 168.2 kb | Distal (>10kb) Multiome | 152 | |
| chrX:40,014,248–40,015,286 | 162.4 kb | Distal (>10kb) Multiome | 617 | |
| chrX:40,090,100–40,090,877 | 5.3 kb | Proximal (<10kb) | 285 | |
| chrX:40,092,876–40,093,360 | 2.8 kb | Proximal (<10kb) | 118 | |
| chrX:40,094,296–40,094,723 | 1.5 kb | Proximal (<10kb) | 349 | |
| chrX:40,097,449–40,098,830 | 79.4 kb | Distal (>10kb) Multiome | 528 | |
| chrX:40,098,919–40,099,484 | 2.7 kb | Proximal (<10kb) | 298 | |
| chrX:40,100,764–40,101,372 | 4.6 kb | Proximal (<10kb) | 192 | |
| chrX:40,103,671–40,104,197 | 7.5 kb | Proximal (<10kb) | 244 | |
| chrX:40,104,842–40,105,650 | 8.7 kb | Proximal (<10kb) | 416 | |
| chrX:40,106,000–40,106,923 | 9.8 kb | Proximal (<10kb) | 477 | |
| chrX:40,107,229–40,107,928 | 9.2 kb | Proximal (<10kb) | 379 | |
| chrX:40,146,419–40,146,959 | at TSS | At TSS | 289 | |
| chrX:40,153,521–40,154,571 | 23.2 kb | Distal (>10kb) Multiome | 496 | |
| chrX:40,154,674–40,155,242 | 8.0 kb | Proximal (<10kb) | 455 | |
| chrX:40,157,251–40,157,705 | 19.8 kb | Distal (>10kb) Multiome | 143 | |
| chrX:40,158,041–40,158,745 | 18.9 kb | Distal (>10kb) Multiome | 405 | |
| chrX:40,167,909–40,168,096 | 9.2 kb | Proximal (<10kb) | 153 | |
| chrX:40,169,190–40,170,089 | 7.7 kb | Proximal (<10kb) Multiome | 620 | |
| chrX:40,175,263–40,175,865 | 1.5 kb | Proximal (<10kb) | 618 | |
| chrX:40,176,539–40,176,911 | 417 bp | At TSS | 414 | |
| chrX:40,474,058–40,474,871 | 297.1 kb | Distal (>10kb) Multiome HiCAR | 312 |
Genomic view of the BCOR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.