This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative promoter usage and splicing result in multiple transcript variants, including SREBP-1a and SREBP-1c, which correspond to RefSeq transcript variants 2 and 3, respectively. [provided by RefSeq, Nov 2017]
Transcription factors with Perturb-seq knockdown data for SREBF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SREBF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SREBF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:17,591,221–17,592,219 | 245.3 kb | Distal (>10kb) Multiome | 945 | |
| chr17:17,680,744–17,682,037 | 155.7 kb | Distal (>10kb) Multiome | 507 | |
| chr17:17,682,791–17,683,426 | 154.0 kb | Distal (>10kb) Multiome | 510 | |
| chr17:17,693,050–17,694,108 | 143.6 kb | Distal (>10kb) Multiome | 549 | |
| chr17:17,694,284–17,695,355 | 142.2 kb | Distal (>10kb) Multiome | 703 | |
| chr17:17,700,114–17,700,885 | 136.5 kb | Distal (>10kb) Multiome | 327 | |
| chr17:17,724,458–17,725,494 | 111.9 kb | Distal (>10kb) Multiome | 283 | |
| chr17:17,751,962–17,752,874 | 84.7 kb | Distal (>10kb) Multiome | 640 | |
| chr17:17,780,889–17,783,985 | 55.9 kb | Distal (>10kb) Multiome | 655 | |
| chr17:17,792,432–17,793,087 | 44.1 kb | Distal (>10kb) Multiome | 135 | |
| chr17:17,809,458–17,811,066 | 27.0 kb | Distal (>10kb) Multiome | 371 | |
| chr17:17,811,471–17,812,921 | 24.6 kb | Distal (>10kb) Multiome | 664 | |
| chr17:17,823,156–17,824,542 | 13.2 kb | Distal (>10kb) Multiome | 743 | |
| chr17:17,835,765–17,838,695 | 616 bp | At TSS Multiome | 1030 | |
| chr17:17,839,788–17,841,046 | 3.3 kb | Proximal (<10kb) Multiome | 927 | |
| chr17:17,921,363–17,921,988 | 84.7 kb | Distal (>10kb) Multiome | 341 | |
| chr17:17,943,271–17,943,954 | 106.6 kb | Distal (>10kb) Multiome | 143 | |
| chr17:17,971,984–17,973,164 | 135.6 kb | Distal (>10kb) Multiome | 716 | |
| chr17:18,035,659–18,036,594 | 199.0 kb | Distal (>10kb) Multiome | 186 | |
| chr17:18,038,656–18,040,279 | 202.3 kb | Distal (>10kb) Multiome | 839 |
Genomic view of the SREBF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.