Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including regulation of gene expression; regulation of signal transduction; and transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MAZ. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAZ upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAZ, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:29,594,581–29,595,807 | 210.7 kb | Distal (>10kb) Multiome | 486 | |
| chr16:29,613,063–29,614,058 | 192.4 kb | Distal (>10kb) Multiome | 302 | |
| chr16:29,614,664–29,615,288 | 191.1 kb | Distal (>10kb) Multiome | 247 | |
| chr16:29,666,524–29,667,045 | 139.3 kb | Distal (>10kb) Multiome | 338 | |
| chr16:29,678,867–29,679,831 | 126.9 kb | Distal (>10kb) Multiome | 783 | |
| chr16:29,708,839–29,709,431 | 97.0 kb | Distal (>10kb) Multiome | 96 | |
| chr16:29,709,743–29,710,091 | 96.1 kb | Distal (>10kb) Multiome | 21 | |
| chr16:29,784,957–29,785,426 | 20.9 kb | Distal (>10kb) Multiome | 452 | |
| chr16:29,790,073–29,791,192 | 15.5 kb | Distal (>10kb) Multiome | 1003 | |
| chr16:29,804,592–29,808,172 | 298 bp | At TSS Multiome | 1275 | |
| chr16:29,810,746–29,812,649 | 6.3 kb | Proximal (<10kb) Multiome | 826 | |
| chr16:29,815,828–29,817,186 | 10.0 kb | Distal (>10kb) Multiome | 1006 | |
| chr16:29,862,597–29,863,901 | 57.3 kb | Distal (>10kb) Multiome | 953 | |
| chr16:29,876,281–29,878,282 | 71.6 kb | Distal (>10kb) Multiome | 319 | |
| chr16:29,899,174–29,900,833 | 93.4 kb | Distal (>10kb) Multiome | 1019 | |
| chr16:29,925,692–29,926,784 | 120.1 kb | Distal (>10kb) Multiome | 912 | |
| chr16:29,961,477–29,962,530 | 155.9 kb | Distal (>10kb) Multiome | 848 | |
| chr16:29,973,238–29,974,906 | 167.6 kb | Distal (>10kb) Multiome | 935 | |
| chr16:29,994,888–29,996,728 | 190.0 kb | Distal (>10kb) Multiome | 1080 | |
| chr16:30,021,215–30,021,860 | 215.5 kb | Distal (>10kb) Multiome HiCAR | 764 | |
| chr16:30,052,803–30,053,364 | 247.0 kb | Distal (>10kb) Multiome | 989 | |
| chr16:30,063,722–30,066,296 | 258.0 kb | Distal (>10kb) Multiome | 1209 | |
| chr16:30,075,490–30,076,439 | 269.9 kb | Distal (>10kb) Multiome | 828 | |
| chr16:30,090,881–30,092,910 | 286.7 kb | Distal (>10kb) Multiome | 1101 | |
| chr16:30,095,557–30,096,839 | 290.2 kb | Distal (>10kb) Multiome | 824 |
Genomic view of the MAZ locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.