MYC

MYC

MYC proto-oncogene, bHLH transcription factor | MYCC, bHLHe39, c-Myc

This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]

Developmental clusters: GC4

Biological processes 87 terms

DNA binding (GO:0003677)DNA binding (GO:0003677)DNA damage response (GO:0006974)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor binding (GO:0140297)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)E-box binding (GO:0070888)ERK1 and ERK2 cascade (GO:0070371)G1/S transition of mitotic cell cycle (GO:0000082)MAPK cascade (GO:0000165)Myc-Max complex (GO:0071943)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)SCF ubiquitin ligase complex binding (GO:1905761)branching involved in ureteric bud morphogenesis (GO:0001658)cellular response to UV (GO:0034644)cellular response to hypoxia (GO:0071456)cellular response to xenobiotic stimulus (GO:0071466)chromatin (GO:0000785)chromatin (GO:0000785)chromatin (GO:0000785)chromatin remodeling (GO:0006338)chromosome (GO:0005694)chromosome organization (GO:0051276)core promoter sequence-specific DNA binding (GO:0001046)cytoplasm (GO:0005737)fibroblast apoptotic process (GO:0044346)identical protein binding (GO:0042802)intracellular iron ion homeostasis (GO:0006879)negative regulation of apoptotic process (GO:0043066)negative regulation of cell division (GO:0051782)negative regulation of fibroblast proliferation (GO:0048147)negative regulation of gene expression via chromosomal CpG island methylation (GO:0044027)negative regulation of monocyte differentiation (GO:0045656)negative regulation of stress-activated MAPK cascade (GO:0032873)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription initiation by RNA polymerase II (GO:0060633)nucleolus (GO:0005730)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of cell population proliferation (GO:0008284)positive regulation of cell population proliferation (GO:0008284)positive regulation of epithelial cell proliferation (GO:0050679)positive regulation of fibroblast proliferation (GO:0048146)positive regulation of fibroblast proliferation (GO:0048146)positive regulation of gene expression (GO:0010628)positive regulation of gene expression (GO:0010628)positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902255)positive regulation of mesenchymal cell proliferation (GO:0002053)positive regulation of metanephric cap mesenchymal cell proliferation (GO:0090096)positive regulation of miRNA transcription (GO:1902895)positive regulation of telomere maintenance (GO:0032206)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein dimerization activity (GO:0046983)protein-DNA complex disassembly (GO:0032986)protein-containing complex (GO:0032991)protein-containing complex binding (GO:0044877)rRNA metabolic process (GO:0016072)regulation of DNA-templated transcription (GO:0006355)regulation of cell cycle process (GO:0010564)regulation of gene expression (GO:0010468)regulation of gene expression (GO:0010468)regulation of somatic stem cell population maintenance (GO:1904672)regulation of telomere maintenance (GO:0032204)regulation of transcription by RNA polymerase II (GO:0006357)response to growth factor (GO:0070848)response to xenobiotic stimulus (GO:0009410)transcription coregulator binding (GO:0001221)

Expression (TPM)

TFs regulating MYC 0 TFs

Transcription factors with Perturb-seq knockdown data for MYC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MYC

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility	Element	Dist. to TSS	Link type	TFs
	chr8:126,824,441–126,825,287	911.2 kb	Distal (>10kb) Multiome HiCAR	383
	chr8:127,618,811–127,619,872	116.8 kb	Distal (>10kb) Multiome	163
	chr8:127,732,588–127,733,103	2.9 kb	Proximal (<10kb)	122
	chr8:127,733,783–127,736,880	985 bp	At TSS Multiome	1123
	chr8:127,736,970–127,739,571	3.1 kb	Proximal (<10kb) Multiome	736
	chr8:127,741,622–127,741,928	5.6 kb	Proximal (<10kb)	421
	chr8:127,742,787–127,743,497	6.7 kb	Proximal (<10kb)	428
	chr8:127,793,785–127,794,960	58.3 kb	Distal (>10kb) Multiome	671
	chr8:127,809,701–127,811,172	74.2 kb	Distal (>10kb) Multiome HiCAR	536
	chr8:127,817,766–127,818,945	82.2 kb	Distal (>10kb) Multiome	295
	chr8:127,854,279–127,855,978	119.2 kb	Distal (>10kb) Multiome	526
	chr8:127,866,850–127,868,020	131.3 kb	Distal (>10kb) Multiome HiCAR	355
	chr8:128,313,424–128,315,244	577.9 kb	Distal (>10kb) Multiome HiCAR	397
	chr8:129,515,453–129,516,252	1779.7 kb	Distal (>10kb) Multiome HiCAR	248

Genome Browser

Genomic view of the MYC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.