This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for BRD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BRD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BRD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:133,991,125–133,993,807 | 75.3 kb | Distal (>10kb) Multiome | 819 | |
| chr9:134,024,630–134,026,342 | 42.8 kb | Distal (>10kb) Multiome | 742 | |
| chr9:134,067,300–134,068,908 | 230 bp | At TSS Multiome | 721 | |
| chr9:134,135,166–134,136,822 | 67.9 kb | Distal (>10kb) Multiome | 790 | |
| chr9:134,325,382–134,326,571 | 258.2 kb | Distal (>10kb) Multiome | 544 |
Genomic view of the BRD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.