The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015]
Transcription factors with Perturb-seq knockdown data for THOP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = THOP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of THOP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:2,489,041–2,489,512 | 296.2 kb | Distal (>10kb) Multiome | 276 | |
| chr19:2,540,631–2,541,164 | 244.6 kb | Distal (>10kb) Multiome | 646 | |
| chr19:2,578,493–2,579,701 | 206.1 kb | Distal (>10kb) Multiome | 763 | |
| chr19:2,581,128–2,581,843 | 204.1 kb | Distal (>10kb) Multiome | 206 | |
| chr19:2,588,132–2,588,925 | 197.1 kb | Distal (>10kb) Multiome | 436 | |
| chr19:2,598,968–2,599,665 | 186.2 kb | Distal (>10kb) Multiome | 683 | |
| chr19:2,602,339–2,602,846 | 182.9 kb | Distal (>10kb) Multiome | 233 | |
| chr19:2,611,021–2,611,484 | 174.2 kb | Distal (>10kb) Multiome | 611 | |
| chr19:2,702,249–2,703,088 | 82.8 kb | Distal (>10kb) Multiome | 421 | |
| chr19:2,720,222–2,721,513 | 64.4 kb | Distal (>10kb) Multiome | 233 | |
| chr19:2,739,625–2,740,374 | 45.4 kb | Distal (>10kb) Multiome | 1063 | |
| chr19:2,782,866–2,783,778 | 2.1 kb | Proximal (<10kb) Multiome | 998 | |
| chr19:2,784,850–2,785,981 | 100 bp | At TSS Multiome | 682 | |
| chr19:2,819,641–2,820,625 | 34.4 kb | Distal (>10kb) Multiome | 826 | |
| chr19:2,840,664–2,842,136 | 55.8 kb | Distal (>10kb) Multiome | 903 | |
| chr19:2,900,564–2,901,033 | 115.3 kb | Distal (>10kb) Multiome | 686 | |
| chr19:2,944,631–2,945,468 | 159.5 kb | Distal (>10kb) Multiome | 891 | |
| chr19:2,950,070–2,951,291 | 165.3 kb | Distal (>10kb) Multiome | 962 | |
| chr19:2,976,688–2,977,848 | 191.9 kb | Distal (>10kb) Multiome | 715 | |
| chr19:2,983,511–2,984,586 | 198.6 kb | Distal (>10kb) Multiome | 523 | |
| chr19:3,024,668–3,025,742 | 239.7 kb | Distal (>10kb) Multiome | 159 | |
| chr19:3,035,442–3,037,057 | 250.9 kb | Distal (>10kb) Multiome | 947 | |
| chr19:3,041,823–3,042,438 | 256.7 kb | Distal (>10kb) Multiome | 173 | |
| chr19:3,045,731–3,048,029 | 260.5 kb | Distal (>10kb) Multiome | 612 | |
| chr19:3,062,260–3,062,861 | 277.0 kb | Distal (>10kb) Multiome | 369 | |
| chr19:4,456,541–4,458,172 | 1672.2 kb | Distal (>10kb) Multiome HiCAR | 757 |
Genomic view of the THOP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.