Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]
Transcription factors with Perturb-seq knockdown data for LSM7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LSM7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LSM7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:2,034,637–2,035,967 | 293.5 kb | Distal (>10kb) Multiome | 368 | |
| chr19:2,041,744–2,042,811 | 286.4 kb | Distal (>10kb) Multiome | 586 | |
| chr19:2,049,171–2,052,365 | 277.3 kb | Distal (>10kb) Multiome | 977 | |
| chr19:2,060,703–2,062,560 | 267.0 kb | Distal (>10kb) Multiome | 913 | |
| chr19:2,095,898–2,097,954 | 231.9 kb | Distal (>10kb) Multiome | 945 | |
| chr19:2,150,726–2,152,200 | 176.8 kb | Distal (>10kb) Multiome | 761 | |
| chr19:2,163,561–2,164,587 | 164.7 kb | Distal (>10kb) Multiome | 750 | |
| chr19:2,235,315–2,237,253 | 92.0 kb | Distal (>10kb) Multiome | 1119 | |
| chr19:2,269,007–2,271,589 | 59.2 kb | Distal (>10kb) Multiome | 983 | |
| chr19:2,273,467–2,274,136 | 54.8 kb | Distal (>10kb) Multiome | 825 | |
| chr19:2,327,828–2,329,150 | 9 bp | At TSS Multiome | 759 | |
| chr19:2,424,712–2,426,099 | 96.7 kb | Distal (>10kb) Multiome | 261 | |
| chr19:2,426,254–2,428,729 | 99.2 kb | Distal (>10kb) Multiome | 1035 | |
| chr19:2,456,419–2,457,381 | 128.4 kb | Distal (>10kb) Multiome | 579 | |
| chr19:2,461,902–2,462,483 | 133.5 kb | Distal (>10kb) Multiome | 382 | |
| chr19:2,462,877–2,463,379 | 134.6 kb | Distal (>10kb) Multiome | 764 | |
| chr19:2,474,412–2,477,595 | 147.5 kb | Distal (>10kb) Multiome | 1104 | |
| chr19:2,478,328–2,479,798 | 150.8 kb | Distal (>10kb) Multiome | 488 | |
| chr19:2,489,041–2,489,512 | 160.7 kb | Distal (>10kb) Multiome | 276 | |
| chr19:2,540,631–2,541,164 | 212.4 kb | Distal (>10kb) Multiome | 646 | |
| chr19:2,578,493–2,579,701 | 250.9 kb | Distal (>10kb) Multiome | 763 | |
| chr19:2,581,128–2,581,843 | 252.8 kb | Distal (>10kb) Multiome | 206 | |
| chr19:2,588,132–2,588,925 | 259.8 kb | Distal (>10kb) Multiome | 436 | |
| chr19:2,598,968–2,599,665 | 270.7 kb | Distal (>10kb) Multiome | 683 | |
| chr19:2,602,339–2,602,846 | 274.0 kb | Distal (>10kb) Multiome | 233 | |
| chr19:2,611,021–2,611,484 | 282.7 kb | Distal (>10kb) Multiome | 611 |
Genomic view of the LSM7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.