This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Transcription factors with Perturb-seq knockdown data for KLF5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KLF5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KLF5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:72,781,287–72,782,590 | 277.0 kb | Distal (>10kb) Multiome | 793 | |
| chr13:73,039,002–73,040,203 | 19.2 kb | Distal (>10kb) Multiome | 182 | |
| chr13:73,058,366–73,060,121 | 75 bp | At TSS Multiome | 776 | |
| chr13:73,061,972–73,062,209 | 3.0 kb | Proximal (<10kb) | 60 | |
| chr13:73,174,238–73,175,616 | 115.7 kb | Distal (>10kb) Multiome | 156 | |
| chr13:73,261,402–73,262,183 | 202.8 kb | Distal (>10kb) Multiome | 227 |
Genomic view of the KLF5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.