The protein encoded by this gene is a nuclear protein that belongs to the family of Kruppel-like C2H2 zinc finger proteins. It functions as a DNA-binding transcription factor by using distinct zinc fingers in different signaling pathways. Thus, it is thought that this gene may have multiple roles in signal transduction during development. Mutations in this gene are associated with nephronophthisis-14 and Joubert syndrome-19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2012]
Transcription factors with Perturb-seq knockdown data for ZNF423. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF423 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF423, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:49,556,863–49,557,813 | 298.8 kb | Distal (>10kb) Multiome | 176 | |
| chr16:49,696,220–49,696,949 | 159.4 kb | Distal (>10kb) Multiome | 136 | |
| chr16:49,754,578–49,755,513 | 101.0 kb | Distal (>10kb) Multiome | 255 | |
| chr16:49,838,622–49,839,188 | 17.2 kb | Distal (>10kb) Multiome | 82 | |
| chr16:49,849,600–49,849,933 | 6.2 kb | Proximal (<10kb) | 34 | |
| chr16:49,853,284–49,853,558 | 2.6 kb | Proximal (<10kb) | 19 | |
| chr16:49,854,387–49,856,396 | 461 bp | At TSS Multiome | 495 | |
| chr16:49,856,552–49,859,437 | 1.1 kb | Proximal (<10kb) Multiome | 535 | |
| chr16:49,876,274–49,877,137 | 20.7 kb | Distal (>10kb) Multiome | 296 | |
| chr16:50,024,713–50,025,833 | 169.1 kb | Distal (>10kb) Multiome | 882 | |
| chr16:50,065,596–50,066,866 | 210.0 kb | Distal (>10kb) Multiome | 839 | |
| chr16:50,152,387–50,154,528 | 297.0 kb | Distal (>10kb) Multiome | 930 |
Genomic view of the ZNF423 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.