Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF770. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF770 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF770, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:34,721,776–34,722,400 | 266.2 kb | Distal (>10kb) Multiome | 275 | |
| chr15:34,754,688–34,755,339 | 233.2 kb | Distal (>10kb) Multiome | 165 | |
| chr15:34,795,012–34,796,020 | 192.7 kb | Distal (>10kb) Multiome | 219 | |
| chr15:34,969,126–34,970,219 | 18.4 kb | Distal (>10kb) Multiome | 886 | |
| chr15:34,986,797–34,987,399 | 825 bp | At TSS | 112 | |
| chr15:34,987,975–34,988,845 | 127 bp | At TSS Multiome | 940 | |
| chr15:34,994,724–34,995,307 | 6.5 kb | Proximal (<10kb) | 36 | |
| chr15:35,018,915–35,019,739 | 31.3 kb | Distal (>10kb) Multiome | 105 | |
| chr15:35,019,863–35,020,882 | 32.4 kb | Distal (>10kb) Multiome | 129 | |
| chr15:35,166,757–35,167,271 | 178.7 kb | Distal (>10kb) Multiome | 280 |
Genomic view of the ZNF770 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.