SP5

Sp5 transcription factor

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within bone morphogenesis and post-anal tail morphogenesis. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-7 DE-7.1 Developmental clusters: GC3

Biological processes 11 terms

DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)chromatin (GO:0000785)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleus (GO:0005634)nucleus (GO:0005634)regulation of transcription by RNA polymerase II (GO:0006357)sequence-specific DNA binding (GO:0043565)

Expression (TPM)

TFs regulating SP5 0 TFs

Transcription factors with Perturb-seq knockdown data for SP5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SP5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SP5

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SP5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr2:170,324,455–170,325,287	390.4 kb	Distal (>10kb) Multiome HiCAR	406
chr2:170,530,034–170,531,403	184.8 kb	Distal (>10kb) Multiome HiCAR	587
chr2:170,696,280–170,697,478	18.2 kb	Distal (>10kb) Multiome	123
chr2:170,711,360–170,712,724	3.3 kb	Proximal (<10kb) Multiome	753
chr2:170,713,092–170,717,699	100 bp	At TSS Multiome	1155
chr2:170,717,975–170,718,437	2.6 kb	Proximal (<10kb)	147
chr2:170,764,641–170,765,221	49.6 kb	Distal (>10kb) Multiome	96
chr2:170,770,133–170,771,632	55.5 kb	Distal (>10kb) Multiome	841
chr2:170,814,981–170,816,480	100.5 kb	Distal (>10kb) Multiome	523
chr2:170,873,044–170,873,708	157.9 kb	Distal (>10kb) Multiome	509
chr2:170,917,144–170,918,588	202.4 kb	Distal (>10kb) Multiome	221
chr2:170,928,198–170,930,434	213.8 kb	Distal (>10kb) Multiome	1135
chr2:170,973,304–170,974,525	258.3 kb	Distal (>10kb) Multiome	906

Genome Browser

Genomic view of the SP5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.