This gene encodes one of testis-specific transcription factors which are essential for spermatogenesis, oogenesis and folliculogenesis. This gene is located on chromosome 13. The proteins encoded by this gene and another testis-specific transcription factor, SOHLH1, can form heterodimers, in addition to homodimers. There is a read-through locus (GeneID: 100526761) that shares sequence identity with this gene and the upstream CCDC169 (GeneID: 728591). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for SOHLH2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SOHLH2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SOHLH2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:36,130,286–36,131,909 | 83.4 kb | Distal (>10kb) Multiome | 348 | |
| chr13:36,297,356–36,298,329 | 83.3 kb | Distal (>10kb) Multiome | 597 | |
| chr13:36,298,442–36,299,112 | 84.4 kb | Distal (>10kb) Multiome | 192 | |
| chr13:36,324,257–36,325,131 | 110.1 kb | Distal (>10kb) Multiome | 143 | |
| chr13:36,345,510–36,347,162 | 132.2 kb | Distal (>10kb) Multiome | 776 | |
| chr13:36,431,409–36,432,761 | 217.6 kb | Distal (>10kb) Multiome | 369 |
Genomic view of the SOHLH2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.