Enables beta-catenin binding activity and transcription cis-regulatory region binding activity. Involved in positive regulation of cell population proliferation; response to estrogen; and transcription initiation-coupled chromatin remodeling. Acts upstream of or within DNA damage response. Located in nucleus. Part of MLL1 complex; MLL3/4 complex; and Set1C/COMPASS complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ASH2L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ASH2L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ASH2L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:37,821,399–37,822,221 | 283.7 kb | Distal (>10kb) Multiome | 284 | |
| chr8:37,826,056–37,826,968 | 278.9 kb | Distal (>10kb) Multiome | 259 | |
| chr8:37,849,554–37,850,089 | 255.6 kb | Distal (>10kb) Multiome | 929 | |
| chr8:37,898,759–37,900,024 | 206.0 kb | Distal (>10kb) Multiome | 956 | |
| chr8:37,915,980–37,916,519 | 189.2 kb | Distal (>10kb) Multiome | 465 | |
| chr8:37,965,216–37,966,371 | 139.9 kb | Distal (>10kb) Multiome | 177 | |
| chr8:38,015,136–38,015,926 | 90.0 kb | Distal (>10kb) Multiome | 59 | |
| chr8:38,029,913–38,031,249 | 75.1 kb | Distal (>10kb) Multiome | 948 | |
| chr8:38,066,984–38,067,582 | 38.3 kb | Distal (>10kb) Multiome | 414 | |
| chr8:38,070,928–38,072,232 | 33.8 kb | Distal (>10kb) Multiome | 282 | |
| chr8:38,104,797–38,106,255 | 164 bp | At TSS Multiome | 954 | |
| chr8:38,108,727–38,109,662 | 3.6 kb | Proximal (<10kb) Multiome | 83 | |
| chr8:38,175,948–38,177,501 | 71.2 kb | Distal (>10kb) Multiome | 870 | |
| chr8:38,230,935–38,232,445 | 126.1 kb | Distal (>10kb) Multiome | 904 | |
| chr8:38,268,159–38,269,673 | 163.7 kb | Distal (>10kb) Multiome | 795 | |
| chr8:38,381,367–38,383,496 | 276.8 kb | Distal (>10kb) Multiome | 956 | |
| chr8:38,385,791–38,387,334 | 280.9 kb | Distal (>10kb) Multiome | 816 |
Genomic view of the ASH2L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.