Enables methylated histone binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including ectoderm development; stem cell differentiation; and stem cell proliferation. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for L3MBTL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = L3MBTL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of L3MBTL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:40,950,581–40,952,237 | 253.9 kb | Distal (>10kb) Multiome | 884 | |
| chr22:41,021,558–41,023,199 | 183.3 kb | Distal (>10kb) Multiome | 978 | |
| chr22:41,091,127–41,092,906 | 113.7 kb | Distal (>10kb) Multiome | 880 | |
| chr22:41,197,028–41,198,019 | 7.8 kb | Proximal (<10kb) Multiome | 640 | |
| chr22:41,204,902–41,205,619 | 51 bp | At TSS Multiome | 640 | |
| chr22:41,237,372–41,238,796 | 32.5 kb | Distal (>10kb) Multiome | 302 | |
| chr22:41,285,539–41,286,833 | 81.0 kb | Distal (>10kb) Multiome | 879 | |
| chr22:41,301,155–41,301,870 | 96.2 kb | Distal (>10kb) Multiome | 658 | |
| chr22:41,380,458–41,382,737 | 176.4 kb | Distal (>10kb) Multiome | 925 | |
| chr22:41,413,486–41,414,305 | 208.6 kb | Distal (>10kb) Multiome | 832 | |
| chr22:41,444,084–41,445,743 | 239.2 kb | Distal (>10kb) Multiome | 607 | |
| chr22:41,446,165–41,449,007 | 241.6 kb | Distal (>10kb) Multiome | 1188 | |
| chr22:41,468,341–41,469,602 | 263.6 kb | Distal (>10kb) Multiome | 920 |
Genomic view of the L3MBTL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.