MNT

MAX network transcriptional repressor | MAD6, MXD6, ROX, bHLHd3, lncRNA-HAL

The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. [provided by RefSeq, Jul 2008]

Member of: DE-5 DE-5.10

Biological processes 24 terms

DNA binding (GO:0003677)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)chromatin (GO:0000785)chromatin binding (GO:0003682)identical protein binding (GO:0042802)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)protein dimerization activity (GO:0046983)regulation of transcription by RNA polymerase II (GO:0006357)transcription by RNA polymerase II (GO:0006366)

Expression (TPM)

TFs regulating MNT 0 TFs

Transcription factors with Perturb-seq knockdown data for MNT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MNT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MNT

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MNT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:2,302,778–2,304,288	97.4 kb	Distal (>10kb) Multiome	770
chr17:2,336,166–2,337,712	64.6 kb	Distal (>10kb) Multiome	896
chr17:2,392,290–2,394,855	8.2 kb	Proximal (<10kb) Multiome	788
chr17:2,396,361–2,397,494	4.1 kb	Proximal (<10kb) Multiome	546
chr17:2,398,260–2,402,837	1.4 kb	Proximal (<10kb) Multiome	1128
chr17:2,511,517–2,512,317	110.9 kb	Distal (>10kb) Multiome	698
chr17:2,592,971–2,594,792	192.6 kb	Distal (>10kb) Multiome	853
chr17:2,691,692–2,692,319	290.9 kb	Distal (>10kb) Multiome	66

Genome Browser

Genomic view of the MNT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.