KLF11

KLF transcription factor 11 | FKLF, MODY7, Tieg3, TIEG2

The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

Biological processes 23 terms

DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)cellular response to endothelin (GO:1990859)chromatin (GO:0000785)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of cell population proliferation (GO:0008285)negative regulation of cell population proliferation (GO:0008285)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of apoptotic process (GO:0043065)protein binding (GO:0005515)regulation of G1/S transition of mitotic cell cycle (GO:2000045)regulation of transcription by RNA polymerase II (GO:0006357)sequence-specific double-stranded DNA binding (GO:1990837)transcription cis-regulatory region binding (GO:0000976)

Expression (TPM)

TFs regulating KLF11 0 TFs

Transcription factors with Perturb-seq knockdown data for KLF11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KLF11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to KLF11

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KLF11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr2:9,770,260–9,771,096	272.9 kb	Distal (>10kb) Multiome HiCAR	321
chr2:9,813,714–9,814,312	229.5 kb	Distal (>10kb) Multiome	406
chr2:9,843,034–9,844,039	200.1 kb	Distal (>10kb) Multiome	965
chr2:9,950,478–9,952,371	92.0 kb	Distal (>10kb) Multiome	704
chr2:10,042,279–10,044,590	561 bp	At TSS Multiome	999
chr2:10,057,234–10,058,147	14.2 kb	Distal (>10kb) Multiome	504
chr2:10,079,477–10,080,916	36.5 kb	Distal (>10kb) Multiome	381
chr2:10,097,234–10,097,850	54.0 kb	Distal (>10kb) Multiome	372
chr2:10,120,050–10,120,940	76.9 kb	Distal (>10kb) Multiome	1054
chr2:10,121,967–10,123,307	79.1 kb	Distal (>10kb) Multiome	958
chr2:10,301,765–10,304,331	259.2 kb	Distal (>10kb) Multiome	899

Genome Browser

Genomic view of the KLF11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.