Predicted to enable histone deacetylase binding activity; transcription coactivator activity; and transcription corepressor activity. Involved in chromatin remodeling and negative regulation of DNA-templated transcription. Located in nucleoplasm. Part of NuRD complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MTA3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTA3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTA3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:42,360,768–42,362,053 | 207.1 kb | Distal (>10kb) Multiome | 866 | |
| chr2:42,492,549–42,495,300 | 74.6 kb | Distal (>10kb) Multiome | 920 | |
| chr2:42,545,606–42,546,387 | 22.5 kb | Distal (>10kb) Multiome | 211 | |
| chr2:42,567,798–42,569,119 | 108 bp | At TSS Multiome | 598 | |
| chr2:42,792,290–42,793,678 | 224.1 kb | Distal (>10kb) Multiome | 808 | |
| chr2:42,809,783–42,811,471 | 241.7 kb | Distal (>10kb) Multiome | 1125 |
Genomic view of the MTA3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.