This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FOXP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FOXP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FOXP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:71,008,099–71,009,092 | 575.1 kb | Distal (>10kb) Multiome HiCAR | 157 | |
| chr3:71,063,872–71,065,709 | 518.6 kb | Distal (>10kb) Multiome | 612 | |
| chr3:71,208,073–71,209,114 | 375.1 kb | Distal (>10kb) Multiome | 706 | |
| chr3:71,305,225–71,306,403 | 277.7 kb | Distal (>10kb) Multiome | 306 | |
| chr3:71,581,323–71,584,986 | 128 bp | At TSS Multiome | 948 | |
| chr3:71,724,579–71,725,985 | 141.6 kb | Distal (>10kb) Multiome | 430 | |
| chr3:71,729,677–71,730,351 | 146.3 kb | Distal (>10kb) Multiome | 234 | |
| chr3:71,753,029–71,755,146 | 170.3 kb | Distal (>10kb) Multiome | 301 | |
| chr3:71,784,668–71,785,699 | 201.5 kb | Distal (>10kb) Multiome | 273 | |
| chr3:71,875,256–71,876,589 | 292.0 kb | Distal (>10kb) Multiome | 430 |
Genomic view of the FOXP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.