HES6

hes family bHLH transcription factor 6 | bHLHb41

This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Dec 2008]

Member of: DE-1

Biological processes 27 terms

DNA binding (GO:0003677)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)anterior/posterior pattern specification (GO:0009952)chromatin (GO:0000785)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein dimerization activity (GO:0046983)regulation of DNA-templated transcription (GO:0006355)regulation of neurogenesis (GO:0050767)sequence-specific double-stranded DNA binding (GO:1990837)sequence-specific double-stranded DNA binding (GO:1990837)transcription regulator complex (GO:0005667)transcription regulator complex (GO:0005667)transcription regulator inhibitor activity (GO:0140416)transcription regulator inhibitor activity (GO:0140416)

Expression (TPM)

TFs regulating HES6 0 TFs

Transcription factors with Perturb-seq knockdown data for HES6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HES6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to HES6

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HES6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr2:237,966,278–237,967,676	273.8 kb	Distal (>10kb) Multiome	861
chr2:238,060,279–238,061,878	179.8 kb	Distal (>10kb) Multiome	970
chr2:238,098,121–238,098,760	142.1 kb	Distal (>10kb) Multiome	222
chr2:238,158,343–238,159,417	81.7 kb	Distal (>10kb) Multiome	343
chr2:238,203,020–238,204,239	36.9 kb	Distal (>10kb) Multiome	702
chr2:238,231,577–238,231,785	8.2 kb	Proximal (<10kb)	248
chr2:238,234,336–238,234,816	6.1 kb	Proximal (<10kb) Multiome	543
chr2:238,238,732–238,241,847	556 bp	At TSS Multiome	1072
chr2:238,287,738–238,289,462	48.3 kb	Distal (>10kb) Multiome	893
chr2:238,289,660–238,290,518	49.7 kb	Distal (>10kb) Multiome	315
chr2:238,319,822–238,321,188	79.8 kb	Distal (>10kb) Multiome	623
chr2:238,425,866–238,427,628	186.2 kb	Distal (>10kb) Multiome	920

Genome Browser

Genomic view of the HES6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.