FOXF2 encodes forkhead box F2, one of many human homologues of the Drosophila melanogaster transcription factor forkhead. FOXF2 is expressed in lung and placenta, and has been shown to transcriptionally activate several lung-specific genes. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FOXF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FOXF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FOXF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:1,381,488–1,382,145 | 7.4 kb | Proximal (<10kb) | 456 | |
| chr6:1,382,524–1,384,552 | 5.0 kb | Proximal (<10kb) | 233 | |
| chr6:1,389,074–1,391,268 | at TSS | At TSS | 365 | |
| chr6:1,392,789–1,393,963 | 3.2 kb | Proximal (<10kb) | 153 | |
| chr6:1,397,074–1,397,250 | 7.5 kb | Proximal (<10kb) | 349 |
Genomic view of the FOXF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.