This gene encodes a member of the evolutionarily conserved TIMM (translocase of inner mitochondrial membrane) family of proteins that function as chaperones in the import of proteins from the cytoplasm into the mitochondrial inner membrane. Proteins of this family play a role in collecting substrate proteins from the translocase of the outer mitochondrial membrane (TOM) complex and delivering them to either the sorting and assembly machinery in the outer mitochondrial membrane (SAM) complex or the TIMM22 complex in the inner mitochondrial membrane. The encoded protein and the translocase of mitochondrial inner membrane 8a protein form a 70 kDa complex in the intermembrane space. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for TIMM13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TIMM13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TIMM13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:2,150,726–2,152,200 | 275.8 kb | Distal (>10kb) Multiome | 761 | |
| chr19:2,163,561–2,164,587 | 263.7 kb | Distal (>10kb) Multiome | 750 | |
| chr19:2,235,315–2,237,253 | 191.0 kb | Distal (>10kb) Multiome | 1119 | |
| chr19:2,269,007–2,271,589 | 158.2 kb | Distal (>10kb) Multiome | 983 | |
| chr19:2,273,467–2,274,136 | 153.8 kb | Distal (>10kb) Multiome | 825 | |
| chr19:2,327,828–2,329,150 | 99.0 kb | Distal (>10kb) Multiome | 759 | |
| chr19:2,424,712–2,426,099 | 2.3 kb | Proximal (<10kb) Multiome | 261 | |
| chr19:2,426,254–2,428,729 | 189 bp | At TSS Multiome | 1035 | |
| chr19:2,456,419–2,457,381 | 29.4 kb | Distal (>10kb) Multiome | 579 | |
| chr19:2,461,902–2,462,483 | 34.5 kb | Distal (>10kb) Multiome | 382 | |
| chr19:2,462,877–2,463,379 | 35.6 kb | Distal (>10kb) Multiome | 764 | |
| chr19:2,474,412–2,477,595 | 48.5 kb | Distal (>10kb) Multiome | 1104 | |
| chr19:2,478,328–2,479,798 | 51.8 kb | Distal (>10kb) Multiome | 488 | |
| chr19:2,489,041–2,489,512 | 61.7 kb | Distal (>10kb) Multiome | 276 | |
| chr19:2,540,631–2,541,164 | 113.4 kb | Distal (>10kb) Multiome | 646 | |
| chr19:2,578,493–2,579,701 | 151.9 kb | Distal (>10kb) Multiome | 763 | |
| chr19:2,581,128–2,581,843 | 153.8 kb | Distal (>10kb) Multiome | 206 | |
| chr19:2,588,132–2,588,925 | 160.8 kb | Distal (>10kb) Multiome | 436 | |
| chr19:2,598,968–2,599,665 | 171.7 kb | Distal (>10kb) Multiome | 683 | |
| chr19:2,602,339–2,602,846 | 175.0 kb | Distal (>10kb) Multiome | 233 | |
| chr19:2,611,021–2,611,484 | 183.7 kb | Distal (>10kb) Multiome HiCAR | 611 | |
| chr19:2,702,249–2,703,088 | 275.2 kb | Distal (>10kb) Multiome | 421 | |
| chr19:2,720,222–2,721,513 | 293.5 kb | Distal (>10kb) Multiome | 233 |
Genomic view of the TIMM13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.