This gene encodes a member of the arginine/serine-rich splicing factor protein family. The encoded protein can either activate or repress splicing, depending on its phosphorylation state and its interaction partners. Multiple transcript variants have been found for this gene. There is a pseudogene of this gene on chromosome 13. [provided by RefSeq, Jun 2014]
Transcription factors with Perturb-seq knockdown data for SRSF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SRSF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SRSF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:57,750,076–57,750,566 | 257.0 kb | Distal (>10kb) Multiome | 85 | |
| chr17:57,756,756–57,757,413 | 250.1 kb | Distal (>10kb) Multiome | 131 | |
| chr17:57,783,050–57,783,717 | 223.8 kb | Distal (>10kb) Multiome | 468 | |
| chr17:57,833,107–57,833,593 | 174.0 kb | Distal (>10kb) Multiome | 406 | |
| chr17:57,849,786–57,850,720 | 157.1 kb | Distal (>10kb) Multiome HiCAR | 1079 | |
| chr17:57,851,171–57,852,883 | 154.7 kb | Distal (>10kb) Multiome HiCAR | 649 | |
| chr17:57,860,878–57,862,423 | 145.9 kb | Distal (>10kb) Multiome HiCAR | 875 | |
| chr17:57,868,191–57,868,869 | 138.7 kb | Distal (>10kb) Multiome HiCAR | 587 | |
| chr17:57,874,428–57,875,544 | 132.5 kb | Distal (>10kb) Multiome HiCAR | 639 | |
| chr17:57,892,543–57,893,376 | 114.5 kb | Distal (>10kb) Multiome | 825 | |
| chr17:57,901,269–57,901,796 | 105.6 kb | Distal (>10kb) Multiome | 289 | |
| chr17:57,926,939–57,927,538 | 80.1 kb | Distal (>10kb) Multiome | 259 | |
| chr17:57,954,427–57,955,892 | 51.9 kb | Distal (>10kb) Multiome | 612 | |
| chr17:57,987,092–57,989,001 | 18.9 kb | Distal (>10kb) Multiome | 1036 | |
| chr17:57,995,337–57,995,718 | 9.4 kb | Proximal (<10kb) | 475 | |
| chr17:57,999,584–57,999,955 | 5.2 kb | Proximal (<10kb) | 208 | |
| chr17:58,006,337–58,008,268 | 261 bp | At TSS Multiome | 1147 | |
| chr17:58,082,555–58,084,952 | 76.0 kb | Distal (>10kb) Multiome HiCAR | 835 | |
| chr17:58,156,945–58,157,756 | 150.0 kb | Distal (>10kb) Multiome | 235 | |
| chr17:58,218,800–58,219,654 | 212.0 kb | Distal (>10kb) Multiome | 890 | |
| chr17:58,249,147–58,250,121 | 242.5 kb | Distal (>10kb) Multiome | 737 |
Genomic view of the SRSF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.