The protein encoded by this gene is a member of the POU-domain transcription factor family and may be involved in maintaining visual system neurons in the retina. The level of the encoded protein is also elevated in a majority of breast cancers, resulting in accelerated tumor growth. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for POU4F2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POU4F2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POU4F2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:146,632,965–146,633,695 | 5.2 kb | Proximal (<10kb) | 63 | |
| chr4:146,636,863–146,637,546 | 1.3 kb | Proximal (<10kb) | 481 | |
| chr4:146,637,802–146,639,468 | at TSS | At TSS | 313 | |
| chr4:146,639,748–146,641,103 | 856 bp | At TSS | 96 | |
| chr4:146,643,946–146,644,107 | 5.1 kb | Proximal (<10kb) | 121 | |
| chr4:146,647,528–146,648,929 | 8.6 kb | Proximal (<10kb) | 297 |
Genomic view of the POU4F2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.