Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MEIS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MEIS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MEIS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:66,345,879–66,346,832 | 87.1 kb | Distal (>10kb) Multiome | 190 | |
| chr2:66,425,278–66,427,069 | 6.4 kb | Proximal (<10kb) | 255 | |
| chr2:66,428,939–66,429,327 | 4.1 kb | Proximal (<10kb) | 154 | |
| chr2:66,430,048–66,431,393 | 2.7 kb | Proximal (<10kb) Multiome | 315 | |
| chr2:66,432,736–66,435,549 | 79 bp | At TSS Multiome | 1026 | |
| chr2:66,437,807–66,438,021 | 4.4 kb | Proximal (<10kb) | 66 | |
| chr2:66,439,258–66,439,733 | 5.8 kb | Proximal (<10kb) | 97 | |
| chr2:66,440,816–66,440,992 | 7.4 kb | Proximal (<10kb) | 59 | |
| chr2:66,445,166–66,446,914 | at TSS | At TSS | 248 | |
| chr2:66,574,778–66,578,522 | 142.1 kb | Distal (>10kb) Multiome HiCAR | 613 | |
| chr2:66,682,065–66,682,940 | 249.2 kb | Distal (>10kb) Multiome | 109 | |
| chr2:67,880,031–67,880,830 | 1447.0 kb | Distal (>10kb) Multiome HiCAR | 160 |
Genomic view of the MEIS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.