chr14:23,493,984–23,494,589

chr14 : 23,493,984 – 23,494,589

605 bp 131 TFs 9 linked genes

This 605 bp open chromatin element is linked to 9 target genes and is bound by 131 transcription factors.

Linked Genes

9 genes

Gene	Expression	Dist. to TSS	Distance	Link type
NGDN		24.7 kb	Distal	Multiome
ZFHX2		57.4 kb	Distal	Multiome+HiCAR
AP1G2		73.4 kb	Distal	Multiome
EFS		128.7 kb	Distal	Multiome
SLC22A17		141.5 kb	Distal	Multiome
PABPN1		172.9 kb	Distal	Multiome
BCL2L2		187.5 kb	Distal	Multiome
PPP1R3E		192.8 kb	Distal	Multiome
HOMEZ		208.2 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

131 transcription factors

ChIP 22Rv1 GSE85558.AR.22Rv1 169 bp overlap

ASH2L 2 datasets

ChIP H1 ENCFF399KAM 605 bp overlap

ChIP WA01 ENCSR850KIP.ASH2L.WA01 512 bp overlap

ChIP WA01 ENCSR000BQU.ATF2.WA01 186 bp overlap

BAP1 2 datasets

ChIP NCI-H1963_shASXL3 GSE145028.BAP1.NCI-H1963_shASXL3 605 bp overlap

ChIP NCI-H1963_shNONT GSE145028.BAP1.NCI-H1963_shNONT 495 bp overlap

BCL11A 1 dataset

Motif DE_72h DE_72h-BCL11A_MA2324.1 7 bp overlap

ChIP WA01_RNF2-R GSE104690.BCOR.WA01_RNF2-R 149 bp overlap

BRD4 10 datasets

ChIP NCI-H1963 GSE145028.BRD4.NCI-H1963 466 bp overlap

ChIP NCI-H1963_shASXL3 GSE145028.BRD4.NCI-H1963_shASXL3 513 bp overlap

ChIP NCI-H1963_shNONT GSE145028.BRD4.NCI-H1963_shNONT 605 bp overlap

ChIP cortical-interneuron GSE117508.BRD4.cortical-interneuron 190 bp overlap

ChIP cortical-interneuron_KCl-pos GSE117508.BRD4.cortical-interneuron_KCl-pos 317 bp overlap

ChIP cortical-interneuron_KCl-pos_JQ1-neg GSE117508.BRD4.cortical-interneuron_KCl-pos_JQ1-neg 240 bp overlap

ChIP cortical-interneuron_R133C_KCl-neg_JQ1-neg GSE117508.BRD4.cortical-interneuron_R133C_KCl-neg_JQ1-neg 444 bp overlap

ChIP cortical-interneuron_R133C_KCl-neg_JQ1-pos GSE117508.BRD4.cortical-interneuron_R133C_KCl-neg_JQ1-pos 233 bp overlap

ChIP cortical-interneuron_R133C_KCl-pos_JQ1-neg GSE117508.BRD4.cortical-interneuron_R133C_KCl-pos_JQ1-neg 538 bp overlap

ChIP cortical-interneuron_R133C_KCl-pos_JQ1-pos GSE117508.BRD4.cortical-interneuron_R133C_KCl-pos_JQ1-pos 200 bp overlap

CCAR2 1 dataset

ChIP Hep-G2 GSE120104.CCAR2.Hep-G2 164 bp overlap

ChIP adult-duodenal-cell GSE115314.CDX2.adult-duodenal-cell 289 bp overlap

CEBPA 1 dataset

ChIP liver ERP002306.CEBPA.liver 138 bp overlap

CEBPZ 1 dataset

ChIP HepG2 ENCFF701TGY 295 bp overlap

CTBP2 1 dataset

ChIP WA01 ENCSR000EUO.CTBP2.WA01 306 bp overlap

ChIP anterior-temporal-cortex_fetal GSE116825.CTCF.anterior-temporal-cortex_fetal 154 bp overlap

DMTF1 1 dataset

ChIP HepG2 ENCFF032QET 379 bp overlap

ChIP HepG2 ENCFF700HHQ 290 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 316 bp overlap

ChIP cardiomyocyte_D9 GSE129986.ETS1.cardiomyocyte_D9 189 bp overlap

ChIP neural progenitor cell ENCFF018MKA 478 bp overlap

EZH2_phosphoT487 1 dataset

ChIP neural_progenitor ENCSR656MXA.EZH2_phosphoT487.neural_progenitor 356 bp overlap

ChIP A-673_1_KRAB_GFP GSE106914.FLI1.A-673_1_KRAB_GFP 175 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 593 bp overlap

ChIP DE DE-FOXA2-2 464 bp overlap

FUBP3 2 datasets

ChIP HepG2 ENCFF281RQN 393 bp overlap

ChIP HepG2 ENCFF281RQN 160 bp overlap

GATA2 4 datasets

ChIP LNCaP_CSFCS GSE69043.GATA2.LNCaP_CSFCS 111 bp overlap

ChIP dermal-fibroblast_alone GSE51025.GATA2.dermal-fibroblast_alone 117 bp overlap

ChIP dermal-fibroblast_alone GSE51025.GATA2.dermal-fibroblast_alone 193 bp overlap

ChIP hiPSC_SLC6ebs GSE107639.GATA2.hiPSC_SLC6ebs 275 bp overlap

GATA3 1 dataset

ChIP Kelly GSE65664.GATA3.Kelly 215 bp overlap

GATA4 5 datasets

ChIP DE DE-GATA4-1 571 bp overlap

ChIP DE DE-GATA4-2 566 bp overlap

ChIP foregut GSE117136.GATA4.foregut 605 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 566 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 265 bp overlap

GATA6 13 datasets

ChIP DE DE-GATA6-1 605 bp overlap

ChIP DE DE-GATA6-2 601 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 574 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 470 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 522 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 560 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 504 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 602 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 601 bp overlap

ChIP foregut GSE117136.GATA6.foregut 552 bp overlap

ChIP foregut_KO GSE117136.GATA6.foregut_KO 396 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 468 bp overlap

ChIP pancreatic-progenitor_KO GSE117136.GATA6.pancreatic-progenitor_KO 264 bp overlap

GLIS1 1 dataset

ChIP HEK293 ENCSR482BBZ.GLIS1.HEK293 224 bp overlap

GTF3A 2 datasets

ChIP HepG2 ENCFF268DGX 376 bp overlap

ChIP HepG2 ENCFF268DGX 146 bp overlap

HNF4A 8 datasets

Motif DE_60h DE_60h-HNF4A_MA0114.5 9 bp overlap

Motif DE_72h DE_72h-HNF4A_MA0114.5 9 bp overlap

ChIP Hep-G2 ENCSR469FBY.HNF4A.Hep-G2 224 bp overlap

ChIP Hep-G2 ERP000209.HNF4A.Hep-G2 215 bp overlap

ChIP Hep-G2 ENCSR000BLF.HNF4A.Hep-G2 214 bp overlap

ChIP Hep-G2 ENCSR000EEU.HNF4A.Hep-G2 131 bp overlap

ChIP HepG2 ENCFF146SSF 361 bp overlap

ChIP HepG2 ENCFF669NAM 261 bp overlap

HNF4G 4 datasets

Motif DE_60h DE_60h-HNF4G_MA0484.3 9 bp overlap

Motif DE_72h DE_72h-HNF4G_MA0484.3 9 bp overlap

ChIP Hep-G2 ENCSR000BNJ.HNF4G.Hep-G2 178 bp overlap

ChIP HepG2 ENCFF323ATZ 291 bp overlap

HOXA3 3 datasets

ChIP Hep-G2 ENCSR999JKC.HOXA3.Hep-G2 185 bp overlap

ChIP HepG2 ENCFF374TCI 457 bp overlap

ChIP HepG2 ENCFF374TCI 250 bp overlap

Hand1::Tcf3 1 dataset

Motif DE_60h DE_60h-Hand1Tcf3_MA0092.2 9 bp overlap

ChIP HepG2 ENCFF140LNG 265 bp overlap

ChIP THP-1 GSE123872.IRF8.THP-1 107 bp overlap

ChIP DE_D1 S08-DE-d1-JUN-exp1 270 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 270 bp overlap

ChIP ESC S34-ESC-d0-JUN-exp2 313 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 312 bp overlap

KLF10 1 dataset

Motif DE_72h DE_72h-KLF10_MA1511.2 9 bp overlap

KLF12 1 dataset

Motif DE_72h DE_72h-KLF12_MA0742.2 9 bp overlap

KLF14 1 dataset

Motif DE_72h DE_72h-KLF14_MA0740.2 9 bp overlap

KLF16 1 dataset

Motif DE_72h DE_72h-KLF16_MA0741.1 11 bp overlap

Motif DE_72h DE_72h-KLF5_MA0599.1 10 bp overlap

Motif DE_72h DE_72h-MAZ_MA1522.2 8 bp overlap

ChIP dopaminergic-neuron_Dopamine_neurons GSE93905.MED1.dopaminergic-neuron_Dopamine_neurons 202 bp overlap

MEIS1 1 dataset

ChIP HepG2 ENCFF706DID 446 bp overlap

ChIP SK-N-AS GSE138295.MYC.SK-N-AS 232 bp overlap

MYCN 2 datasets

ChIP CHP-134 GSE129588.MYCN.CHP-134 268 bp overlap

ChIP NB-1643 GSE138295.MYCN.NB-1643 451 bp overlap

NANOG 5 datasets

ChIP HUES-8 GSE109524.NANOG.HUES-8 507 bp overlap

ChIP WA01 ENCSR000BMT.NANOG.WA01 199 bp overlap

ChIP WA01 ERP004238.NANOG.WA01 285 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 401 bp overlap

ChIP hESC GSE18292.NANOG.hESC 122 bp overlap

NCOR1 1 dataset

ChIP HepG2 ENCFF685NAH 572 bp overlap

NFKBIZ 1 dataset

ChIP Hep-G2 ENCSR235OVI.NFKBIZ.Hep-G2 140 bp overlap

NFYB 3 datasets

ChIP Hep-G2 ENCSR935GZV.NFYB.Hep-G2 226 bp overlap

ChIP HepG2 ENCFF174VYX 288 bp overlap

ChIP WTC11 ENCFF751ZTQ 302 bp overlap

NFYC 2 datasets

ChIP Hep-G2 ENCSR569ARC.NFYC.Hep-G2 220 bp overlap

ChIP HepG2 ENCFF836FYP 288 bp overlap

NR1H2::RXRA 2 datasets

Motif DE_60h DE_60h-NR1H2RXRA_MA0115.1 17 bp overlap

Motif DE_72h DE_72h-NR1H2RXRA_MA0115.1 17 bp overlap

PATZ1 1 dataset

Motif DE_72h DE_72h-PATZ1_MA1961.2 11 bp overlap

PAX3-FOXO1 1 dataset

ChIP RH4 GSE140115.PAX3-FOXO1.RH4 222 bp overlap

PCBP2 2 datasets

ChIP Hep-G2 GSE120104.PCBP2.Hep-G2 370 bp overlap

ChIP Hep-G2 ENCSR945NSF.PCBP2.Hep-G2 364 bp overlap

PDX1 3 datasets

ChIP hiPSC GSE125768.PDX1.hiPSC 287 bp overlap

ChIP hiPSC_derived_PPs GSE106949.PDX1.hiPSC_derived_PPs 252 bp overlap

ChIP pancreatic-progenitor GSE117136.PDX1.pancreatic-progenitor 362 bp overlap

POLR2A 5 datasets

ChIP GM23338 ENCFF450WCS 477 bp overlap

ChIP GM23338 ENCFF450WCS 272 bp overlap

ChIP H1 ENCFF566JSR 540 bp overlap

ChIP H1 ENCFF833NJP 406 bp overlap

ChIP neural cell ENCFF604SPB 385 bp overlap

POU5F1 3 datasets

ChIP HUES-8 GSE109524.POU5F1.HUES-8 503 bp overlap

ChIP hESC_PRIMED GSE69646.POU5F1.hESC_PRIMED 338 bp overlap

ChIP hiPSC GSE56567.POU5F1.hiPSC 220 bp overlap

PRDM9 1 dataset

Motif DE_72h DE_72h-PRDM9_MA1723.2 20 bp overlap

RARA 2 datasets

ChIP hiPSC_D3 GSE109172.RARA.hiPSC_D3 234 bp overlap

ChIP hiPSC_D4 GSE109172.RARA.hiPSC_D4 186 bp overlap

RBBP5 2 datasets

ChIP WA01 ENCSR000AQC.RBBP5.WA01 173 bp overlap

ChIP WA01 ENCSR000AQC.RBBP5.WA01 154 bp overlap

REST 3 datasets

ChIP neural ENCSR000BTV.REST.neural 157 bp overlap

ChIP neural cell ENCFF882LXX 505 bp overlap

ChIP neural cell ENCFF882LXX 298 bp overlap

RXRB 2 datasets

Motif DE_60h DE_60h-RXRB_MA0855.1 14 bp overlap

Motif DE_72h DE_72h-RXRB_MA0855.1 14 bp overlap

RXRG 2 datasets

Motif DE_60h DE_60h-RXRG_MA0856.1 14 bp overlap

Motif DE_72h DE_72h-RXRG_MA0856.1 14 bp overlap

Rxra 2 datasets

Motif DE_60h DE_60h-Rxra_MA0512.2 14 bp overlap

Motif DE_72h DE_72h-Rxra_MA0512.2 14 bp overlap

SMAD2 2 datasets

Motif DE_60h DE_60h-SMAD2_MA1964.2 6 bp overlap

ChIP endoderm GSE29422.SMAD2.endoderm 217 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 583 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 385 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 307 bp overlap

SMAD2_3 3 datasets

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 254 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 494 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 565 bp overlap

SMAD3 1 dataset

ChIP endoderm GSE29422.SMAD3.endoderm 183 bp overlap

SMAD4 1 dataset

ChIP endoderm GSE29422.SMAD4.endoderm 269 bp overlap

SMARCA4 5 datasets

ChIP NGP GSE134626.SMARCA4.NGP 189 bp overlap

ChIP NGP_ARID1A-het GSE134626.SMARCA4.NGP_ARID1A-het 282 bp overlap

ChIP NGP_ARID1A-mut2 GSE134626.SMARCA4.NGP_ARID1A-mut2 488 bp overlap

ChIP hiPSC GSE124903.SMARCA4.hiPSC 271 bp overlap

ChIP hiPSC_WT GSE124903.SMARCA4.hiPSC_WT 181 bp overlap

SMARCC1 1 dataset

ChIP hiPSC_WT GSE124903.SMARCC1.hiPSC_WT 197 bp overlap

SNAI1 1 dataset

ChIP HepG2 ENCFF017SIW 214 bp overlap

SNAI2 1 dataset

ChIP SMS-CTR_shSNAI2 GSE137168.SNAI2.SMS-CTR_shSNAI2 226 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 288 bp overlap

ChIP hESC GSE18292.SOX2.hESC 97 bp overlap

ChIP RH4 GSE116344.SOX8.RH4 262 bp overlap

Motif DE_72h DE_72h-SP1_MA0079.5 9 bp overlap

ChIP H1 ENCFF263FUH 316 bp overlap

ChIP WA01 ENCSR000BIR.SP1.WA01 334 bp overlap

Motif DE_72h DE_72h-SP2_MA0516.3 9 bp overlap

Motif DE_72h DE_72h-SP4_MA0685.2 9 bp overlap

Motif DE_72h DE_72h-SP5_MA1965.2 6 bp overlap

Motif DE_72h DE_72h-SP8_MA0747.2 11 bp overlap

SPI1 2 datasets

ChIP CD34_FETAL GSE70660.SPI1.CD34_FETAL 96 bp overlap

ChIP DC_96h_donorM GSE128834.SPI1.DC_96h_donorM 115 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 183 bp overlap

TAF1 4 datasets

ChIP H1 ENCFF478SZO 432 bp overlap

ChIP WA01 ENCSR000BHO.TAF1.WA01 167 bp overlap

ChIP neural cell ENCFF468SPD 474 bp overlap

ChIP neural cell ENCFF468SPD 270 bp overlap

ChIP hESC GSE122298.TBP.hESC 261 bp overlap

ChIP hESC_8h GSE122298.TBP.hESC_8h 191 bp overlap

ChIP hiPSC_WTa_RNase-pos GSE128135.TBP.hiPSC_WTa_RNase-pos 101 bp overlap

TCF7L1 2 datasets

Motif DE_60h DE_60h-TCF7L1_MA1421.1 12 bp overlap

Motif DE_72h DE_72h-TCF7L1_MA1421.1 12 bp overlap

TEAD1 1 dataset

Motif DE_60h DE_60h-TEAD1_MA0090.4 9 bp overlap

TEAD2 1 dataset

Motif DE_60h DE_60h-TEAD2_MA1121.2 7 bp overlap

TEAD3 1 dataset

Motif DE_60h DE_60h-TEAD3_MA0808.1 8 bp overlap

TEAD4 2 datasets

Motif DE_60h DE_60h-TEAD4_MA0809.3 8 bp overlap

ChIP H1 ENCFF778PAX 245 bp overlap

ChIP hESC_DIFF GSE39912.TP53.hESC_DIFF 272 bp overlap

Motif DE_72h DE_72h-Wt1_MA1627.2 10 bp overlap

ChIP WA01 ENCSR000BKD.YY1.WA01 123 bp overlap

ZBTB46 2 datasets

ChIP HepG2 ENCFF806TPY 421 bp overlap

ChIP HepG2 ENCFF806TPY 182 bp overlap

ChIP SK-N-SH_all-trans-retinoic-acid_6-uM_48-hour ENCSR581GUY.ZFP3.SK-N-SH_all-trans-retinoic-acid_6-uM_48-hour 204 bp overlap

ChIP HepG2 ENCFF106ELT 131 bp overlap

ZKSCAN1 1 dataset

Motif DE_72h DE_72h-ZKSCAN1_MA1585.2 9 bp overlap

ZKSCAN5 1 dataset

Motif DE_72h DE_72h-ZKSCAN5_MA1652.2 9 bp overlap

ZNF101 1 dataset

ChIP HepG2 ENCFF152QRL 315 bp overlap

ZNF136 1 dataset

ChIP HepG2 ENCFF188PQX 392 bp overlap

ZNF140 2 datasets

Motif DE_60h DE_60h-ZNF140_MA1589.2 19 bp overlap

Motif DE_72h DE_72h-ZNF140_MA1589.2 19 bp overlap

ZNF148 1 dataset

Motif DE_72h DE_72h-ZNF148_MA1653.2 10 bp overlap

ZNF221 1 dataset

ChIP HepG2 ENCFF374BUN 505 bp overlap

ZNF264 1 dataset

ChIP HepG2 ENCFF453WJV 296 bp overlap

ZNF276 1 dataset

ChIP HepG2 ENCFF431WQQ 411 bp overlap

ZNF281 2 datasets

Motif DE_72h DE_72h-ZNF281_MA1630.3 10 bp overlap

ChIP HepG2 ENCFF585QNU 325 bp overlap

ZNF318 1 dataset

ChIP HepG2 ENCFF054INI 314 bp overlap

ZNF33B 1 dataset

ChIP HepG2 ENCFF921KSE 408 bp overlap

ZNF341 4 datasets

ChIP HEK293 ENCFF944VMC 364 bp overlap

ChIP HEK293 ENCFF944VMC 364 bp overlap

ChIP HEK293 ENCSR185FOY.ZNF341.HEK293 394 bp overlap

ChIP HEK293 GSE76494.ZNF341.HEK293 206 bp overlap

ZNF383 2 datasets

ChIP HepG2 ENCFF358SRK 590 bp overlap

ChIP HepG2 ENCFF358SRK 383 bp overlap

ZNF449 1 dataset

ChIP HEK293 GSE76494.ZNF449.HEK293 123 bp overlap

ZNF467 1 dataset

ChIP HEK293 GSE76494.ZNF467.HEK293 272 bp overlap

ZNF483 2 datasets

ChIP HepG2 ENCFF464ZKH 315 bp overlap

ChIP HepG2 ENCFF464ZKH 452 bp overlap

ZNF510 1 dataset

ChIP HepG2 ENCFF088QOO 439 bp overlap

ZNF530 1 dataset

Motif DE_72h DE_72h-ZNF530_MA1981.2 14 bp overlap

ZNF547 1 dataset

ChIP HepG2 ENCFF834XWI 452 bp overlap

ZNF548 1 dataset

ChIP HepG2 ENCFF586TZH 414 bp overlap

ZNF556 1 dataset

ChIP HepG2 ENCFF008WIK 412 bp overlap

ZNF558 1 dataset

Motif DE_60h DE_60h-ZNF558_MA2335.1 29 bp overlap

ZNF577 1 dataset

ChIP HepG2 ENCFF980BRD 353 bp overlap

ZNF608 1 dataset

ChIP HepG2 ENCFF713QUJ 487 bp overlap

ZNF644 1 dataset

ChIP HepG2 ENCFF352VGJ 334 bp overlap

ZNF667 2 datasets

Motif DE_60h DE_60h-ZNF667_MA1984.2 11 bp overlap

Motif DE_72h DE_72h-ZNF667_MA1984.2 11 bp overlap

ZNF675 1 dataset

Motif DE_72h DE_72h-ZNF675_MA1714.2 19 bp overlap

ZNF684 1 dataset

Motif DE_72h DE_72h-ZNF684_MA1600.2 14 bp overlap

ZNF691 2 datasets

ChIP HepG2 ENCFF427OHT 388 bp overlap

ChIP HepG2 ENCFF427OHT 93 bp overlap

ZNF701 1 dataset

Motif DE_72h DE_72h-ZNF701_MA1987.2 17 bp overlap

ZNF770 2 datasets

Motif DE_60h DE_60h-ZNF770_MA2099.1 8 bp overlap

Motif DE_72h DE_72h-ZNF770_MA2099.1 8 bp overlap

ZNF777 2 datasets

ChIP HepG2 ENCFF362XDA 325 bp overlap

ChIP HepG2 ENCFF362XDA 61 bp overlap

Zfp809 1 dataset

Motif DE_72h DE_72h-Zfp809_MA2125.1 9 bp overlap

Motif DE_72h DE_72h-Zic2_MA1629.2 9 bp overlap