Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF691. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF691 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF691, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:42,657,991–42,659,026 | 188.2 kb | Distal (>10kb) Multiome | 952 | |
| chr1:42,681,723–42,683,347 | 164.3 kb | Distal (>10kb) Multiome | 924 | |
| chr1:42,739,796–42,740,734 | 106.3 kb | Distal (>10kb) Multiome | 365 | |
| chr1:42,765,982–42,767,804 | 79.4 kb | Distal (>10kb) Multiome | 899 | |
| chr1:42,816,354–42,817,722 | 29.4 kb | Distal (>10kb) Multiome | 721 | |
| chr1:42,845,973–42,847,060 | 87 bp | At TSS Multiome | 723 | |
| chr1:42,923,882–42,925,144 | 77.9 kb | Distal (>10kb) Multiome | 878 | |
| chr1:42,957,739–42,959,536 | 112.4 kb | Distal (>10kb) Multiome | 943 | |
| chr1:43,007,293–43,009,203 | 162.2 kb | Distal (>10kb) Multiome | 496 |
Genomic view of the ZNF691 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.