GLIS1 is a GLI (MIM 165220)-related Kruppel-like zinc finger protein that functions as an activator and repressor of transcription (Kim et al., 2002 [PubMed 12042312]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for GLIS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GLIS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GLIS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:53,449,173–53,450,171 | 289.3 kb | Distal (>10kb) Multiome | 106 | |
| chr1:53,469,974–53,470,879 | 268.8 kb | Distal (>10kb) Multiome | 301 | |
| chr1:53,485,511–53,485,959 | 253.5 kb | Distal (>10kb) Multiome HiCAR | 248 | |
| chr1:53,737,700–53,739,665 | 120 bp | At TSS Multiome | 471 | |
| chr1:53,838,019–53,838,779 | 99.3 kb | Distal (>10kb) Multiome | 1058 | |
| chr1:53,889,527–53,890,054 | 150.7 kb | Distal (>10kb) Multiome | 654 | |
| chr1:53,944,886–53,946,958 | 206.8 kb | Distal (>10kb) Multiome | 806 | |
| chr1:53,956,851–53,957,534 | 218.1 kb | Distal (>10kb) Multiome | 255 |
Genomic view of the GLIS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.