This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
Transcription factors with Perturb-seq knockdown data for CTBP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CTBP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CTBP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:124,916,459–124,917,959 | 244.2 kb | Distal (>10kb) Multiome | 843 | |
| chr10:125,048,088–125,048,633 | 112.8 kb | Distal (>10kb) Multiome | 344 | |
| chr10:125,151,246–125,153,639 | 9.0 kb | Proximal (<10kb) Multiome | 450 | |
| chr10:125,158,688–125,159,485 | at TSS | At TSS | 375 | |
| chr10:125,159,798–125,162,908 | 185 bp | At TSS Multiome | 658 | |
| chr10:125,165,483–125,166,068 | 6.8 kb | Proximal (<10kb) | 45 | |
| chr10:125,370,567–125,371,071 | 209.7 kb | Distal (>10kb) Multiome | 159 |
Genomic view of the CTBP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.