This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]
Transcription factors with Perturb-seq knockdown data for RXRG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RXRG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RXRG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:165,185,733–165,186,757 | 259.0 kb | Distal (>10kb) Multiome | 116 | |
| chr1:165,235,066–165,236,469 | 209.6 kb | Distal (>10kb) Multiome | 448 | |
| chr1:165,258,008–165,258,694 | 186.8 kb | Distal (>10kb) Multiome | 239 | |
| chr1:165,323,635–165,324,626 | 120.9 kb | Distal (>10kb) Multiome | 142 | |
| chr1:165,365,159–165,365,914 | 79.6 kb | Distal (>10kb) Multiome | 151 | |
| chr1:165,375,930–165,377,162 | 68.6 kb | Distal (>10kb) Multiome | 364 | |
| chr1:165,439,258–165,439,657 | 5.7 kb | Proximal (<10kb) | 21 | |
| chr1:165,441,235–165,441,973 | 3.4 kb | Proximal (<10kb) | 26 | |
| chr1:165,443,654–165,446,226 | 132 bp | At TSS Multiome | 304 | |
| chr1:165,597,953–165,599,004 | 153.2 kb | Distal (>10kb) Multiome HiCAR | 625 | |
| chr1:165,630,162–165,632,376 | 185.9 kb | Distal (>10kb) Multiome | 964 | |
| chr1:165,697,663–165,699,113 | 253.5 kb | Distal (>10kb) Multiome | 874 |
Genomic view of the RXRG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.