This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for NFKBIZ. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NFKBIZ upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NFKBIZ, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:101,530,192–101,530,904 | 297.5 kb | Distal (>10kb) Multiome | 336 | |
| chr3:101,561,343–101,562,162 | 266.2 kb | Distal (>10kb) Multiome | 783 | |
| chr3:101,573,305–101,575,121 | 253.9 kb | Distal (>10kb) Multiome | 1039 | |
| chr3:101,724,220–101,725,851 | 103.2 kb | Distal (>10kb) Multiome | 749 | |
| chr3:101,778,676–101,779,992 | 48.7 kb | Distal (>10kb) Multiome | 826 | |
| chr3:101,827,455–101,828,137 | at TSS | At TSS | 630 | |
| chr3:101,848,739–101,850,257 | 21.3 kb | Distal (>10kb) Multiome | 854 |
Genomic view of the NFKBIZ locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.