Predicted to enable protein heterodimerization activity and protein homodimerization activity. Predicted to be involved in negative regulation of DNA-templated transcription and positive regulation of DNA-templated transcription. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF318. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF318 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF318, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:43,075,612–43,077,611 | 292.3 kb | Distal (>10kb) Multiome | 744 | |
| chr6:43,096,382–43,096,822 | 273.2 kb | Distal (>10kb) Multiome | 290 | |
| chr6:43,143,296–43,143,802 | 226.0 kb | Distal (>10kb) Multiome | 638 | |
| chr6:43,170,289–43,172,815 | 198.4 kb | Distal (>10kb) Multiome | 1025 | |
| chr6:43,173,720–43,174,910 | 195.1 kb | Distal (>10kb) Multiome | 765 | |
| chr6:43,181,838–43,182,555 | 187.5 kb | Distal (>10kb) Multiome | 874 | |
| chr6:43,228,982–43,229,794 | 140.2 kb | Distal (>10kb) Multiome | 918 | |
| chr6:43,246,576–43,247,616 | 122.4 kb | Distal (>10kb) Multiome | 750 | |
| chr6:43,267,244–43,268,167 | 102.0 kb | Distal (>10kb) Multiome HiCAR | 772 | |
| chr6:43,285,054–43,285,508 | 84.3 kb | Distal (>10kb) Multiome | 68 | |
| chr6:43,308,219–43,309,149 | 60.8 kb | Distal (>10kb) Multiome | 462 | |
| chr6:43,368,714–43,370,143 | 1 bp | At TSS Multiome | 909 | |
| chr6:43,426,936–43,428,340 | 58.0 kb | Distal (>10kb) Multiome | 919 | |
| chr6:43,454,362–43,454,991 | 85.1 kb | Distal (>10kb) Multiome | 686 | |
| chr6:43,477,347–43,478,043 | 107.9 kb | Distal (>10kb) Multiome | 747 | |
| chr6:43,506,605–43,507,204 | 137.3 kb | Distal (>10kb) Multiome HiCAR | 474 | |
| chr6:43,509,337–43,511,016 | 140.7 kb | Distal (>10kb) Multiome HiCAR | 734 | |
| chr6:43,516,463–43,517,515 | 147.4 kb | Distal (>10kb) Multiome | 904 | |
| chr6:43,575,269–43,576,483 | 206.4 kb | Distal (>10kb) Multiome | 1044 | |
| chr6:43,628,488–43,630,447 | 260.5 kb | Distal (>10kb) Multiome | 1157 | |
| chr6:43,635,496–43,636,104 | 266.2 kb | Distal (>10kb) Multiome | 941 | |
| chr6:43,644,712–43,645,902 | 275.7 kb | Distal (>10kb) Multiome | 255 | |
| chr6:43,667,273–43,667,900 | 297.7 kb | Distal (>10kb) Multiome | 625 | |
| chr6:43,667,997–43,668,873 | 298.8 kb | Distal (>10kb) Multiome | 664 |
Genomic view of the ZNF318 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.