Enables RNA polymerase II complex binding activity and enzyme inhibitor activity. Involved in several processes, including mitochondrial fragmentation involved in apoptotic process; regulation of primary metabolic process; and regulation of signal transduction. Located in several cellular components, including mitochondrial matrix; nucleoplasm; and spindle. Part of DBIRD complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CCAR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCAR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCAR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:22,365,087–22,366,071 | 239.2 kb | Distal (>10kb) Multiome | 444 | |
| chr8:22,366,837–22,368,383 | 237.5 kb | Distal (>10kb) Multiome | 859 | |
| chr8:22,440,466–22,441,769 | 163.7 kb | Distal (>10kb) Multiome | 784 | |
| chr8:22,548,856–22,550,046 | 55.2 kb | Distal (>10kb) Multiome | 539 | |
| chr8:22,551,208–22,552,929 | 53.2 kb | Distal (>10kb) Multiome | 406 | |
| chr8:22,561,173–22,562,479 | 42.9 kb | Distal (>10kb) Multiome | 678 | |
| chr8:22,565,061–22,566,429 | 39.0 kb | Distal (>10kb) Multiome | 404 | |
| chr8:22,574,221–22,574,708 | 30.2 kb | Distal (>10kb) Multiome | 527 | |
| chr8:22,578,724–22,579,696 | 25.6 kb | Distal (>10kb) Multiome | 404 | |
| chr8:22,588,723–22,589,902 | 15.5 kb | Distal (>10kb) Multiome | 612 | |
| chr8:22,594,681–22,595,713 | 9.5 kb | Proximal (<10kb) Multiome | 402 | |
| chr8:22,597,003–22,600,290 | 7.3 kb | Proximal (<10kb) Multiome | 889 | |
| chr8:22,604,300–22,605,436 | 9 bp | At TSS Multiome | 1053 | |
| chr8:22,622,764–22,623,329 | 18.3 kb | Distal (>10kb) Multiome | 431 | |
| chr8:22,658,639–22,659,248 | 54.1 kb | Distal (>10kb) Multiome | 290 | |
| chr8:22,668,686–22,669,459 | 64.4 kb | Distal (>10kb) Multiome | 637 | |
| chr8:22,691,357–22,691,921 | 86.9 kb | Distal (>10kb) Multiome | 153 | |
| chr8:22,692,857–22,693,984 | 88.8 kb | Distal (>10kb) Multiome | 490 | |
| chr8:22,694,125–22,696,129 | 90.8 kb | Distal (>10kb) Multiome | 662 | |
| chr8:22,864,299–22,865,847 | 260.3 kb | Distal (>10kb) Multiome | 507 |
Genomic view of the CCAR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.