This gene encodes a member of the Kruppel C2H2-type zinc-finger family of proteins. This encoded protein may function as a transcription factor that regulates the expression of GABA type-A receptors in the brain. Transcripts from this gene have been shown to form stable and abundant circular RNAs. Elevated expression of this gene has been observed in gastric cancer and the encoded protein may stimulate migration and invasion of human gastric cancer cells. [provided by RefSeq, Oct 2016]
Transcription factors with Perturb-seq knockdown data for ZKSCAN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZKSCAN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZKSCAN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:99,616,474–99,617,353 | 398.8 kb | Distal (>10kb) Multiome HiCAR | 1043 | |
| chr7:99,839,578–99,840,069 | 175.7 kb | Distal (>10kb) Multiome | 85 | |
| chr7:99,929,116–99,929,724 | 86.1 kb | Distal (>10kb) Multiome | 300 | |
| chr7:100,015,387–100,016,069 | 7 bp | At TSS Multiome | 744 | |
| chr7:100,049,441–100,050,060 | 34.2 kb | Distal (>10kb) Multiome | 800 | |
| chr7:100,081,134–100,083,000 | 66.3 kb | Distal (>10kb) Multiome | 1160 | |
| chr7:100,088,454–100,089,460 | 73.4 kb | Distal (>10kb) Multiome | 955 | |
| chr7:100,100,270–100,102,380 | 85.1 kb | Distal (>10kb) Multiome | 1102 | |
| chr7:100,119,029–100,120,415 | 104.0 kb | Distal (>10kb) Multiome | 954 | |
| chr7:100,126,675–100,128,006 | 111.6 kb | Distal (>10kb) Multiome | 919 | |
| chr7:100,148,262–100,149,663 | 133.2 kb | Distal (>10kb) Multiome | 846 | |
| chr7:100,158,247–100,159,079 | 143.2 kb | Distal (>10kb) Multiome | 795 | |
| chr7:100,167,090–100,167,783 | 151.9 kb | Distal (>10kb) Multiome | 123 | |
| chr7:100,167,894–100,168,793 | 153.0 kb | Distal (>10kb) Multiome | 439 | |
| chr7:100,171,153–100,171,887 | 155.9 kb | Distal (>10kb) Multiome | 233 | |
| chr7:100,176,986–100,178,152 | 162.0 kb | Distal (>10kb) Multiome | 626 | |
| chr7:100,266,531–100,267,045 | 251.2 kb | Distal (>10kb) Multiome | 24 | |
| chr7:100,270,225–100,270,813 | 255.0 kb | Distal (>10kb) Multiome | 103 | |
| chr7:100,271,732–100,272,774 | 256.7 kb | Distal (>10kb) Multiome | 530 |
Genomic view of the ZKSCAN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.