Enables single-stranded DNA binding activity. Involved in DNA-templated transcription; positive regulation of DNA-templated transcription; and positive regulation of gene expression. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FUBP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FUBP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FUBP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:130,433,040–130,433,900 | 146.1 kb | Distal (>10kb) Multiome | 543 | |
| chr9:130,444,394–130,446,012 | 134.8 kb | Distal (>10kb) Multiome | 568 | |
| chr9:130,446,125–130,446,731 | 133.1 kb | Distal (>10kb) Multiome | 326 | |
| chr9:130,578,979–130,579,997 | 86 bp | At TSS Multiome | 855 | |
| chr9:130,663,509–130,664,148 | 84.5 kb | Distal (>10kb) Multiome | 159 | |
| chr9:130,681,081–130,682,308 | 101.9 kb | Distal (>10kb) Multiome | 836 | |
| chr9:130,689,990–130,690,532 | 110.6 kb | Distal (>10kb) Multiome | 331 | |
| chr9:130,692,215–130,692,841 | 112.9 kb | Distal (>10kb) Multiome | 141 | |
| chr9:130,693,327–130,694,076 | 114.2 kb | Distal (>10kb) Multiome | 752 | |
| chr9:130,712,289–130,713,655 | 133.2 kb | Distal (>10kb) Multiome | 791 | |
| chr9:130,834,623–130,835,640 | 255.6 kb | Distal (>10kb) Multiome | 715 |
Genomic view of the FUBP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.