SPI1
Spi-1 proto-oncogene | OF, PU.1, SFPI1, SPI-1, SPI-A

This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Biological processes 115 terms
DNA binding (GO:0003677)DNA-binding transcription activator activity (GO:0001216)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor binding (GO:0140297)DNA-binding transcription factor binding (GO:0140297)DNA-binding transcription factor binding (GO:0140297)DNA-binding transcription repressor activity (GO:0001217)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)NFAT protein binding (GO:0051525)NFAT protein binding (GO:0051525)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)STAT family protein binding (GO:0097677)TRAIL-activated apoptotic signaling pathway (GO:0036462)cell differentiation (GO:0030154)cellular response to ethanol (GO:0071361)chromatin (GO:0000785)chromatin (GO:0000785)chromatin (GO:0000785)chromatin binding (GO:0003682)chromatin binding (GO:0003682)cis-regulatory region sequence-specific DNA binding (GO:0000987)cis-regulatory region sequence-specific DNA binding (GO:0000987)cis-regulatory region sequence-specific DNA binding (GO:0000987)defense response to tumor cell (GO:0002357)endothelial to hematopoietic transition (GO:0098508)endothelial to hematopoietic transition (GO:0098508)follicular B cell differentiation (GO:0002316)germinal center B cell differentiation (GO:0002314)histone deacetylase binding (GO:0042826)histone deacetylase binding (GO:0042826)immature B cell differentiation (GO:0002327)interleukin-6-mediated signaling pathway (GO:0070102)lipopolysaccharide-mediated signaling pathway (GO:0031663)myeloid leukocyte differentiation (GO:0002573)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of MHC class II biosynthetic process (GO:0045347)negative regulation of adipose tissue development (GO:1904178)negative regulation of adipose tissue development (GO:1904178)negative regulation of canonical NF-kappaB signal transduction (GO:0043124)negative regulation of gene expression (GO:0010629)negative regulation of gene expression (GO:0010629)negative regulation of neutrophil degranulation (GO:0043314)negative regulation of neutrophil degranulation (GO:0043314)negative regulation of non-canonical NF-kappaB signal transduction (GO:1901223)negative regulation of protein localization to chromatin (GO:0120186)negative regulation of protein localization to chromatin (GO:0120186)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)oncogene-induced cell senescence (GO:0090402)oncogene-induced cell senescence (GO:0090402)osteoclast differentiation (GO:0030316)pericyte cell differentiation (GO:1904238)pericyte cell differentiation (GO:1904238)positive regulation of B cell differentiation (GO:0045579)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of antifungal innate immune response (GO:1905036)positive regulation of antifungal innate immune response (GO:1905036)positive regulation of gene expression (GO:0010628)positive regulation of miRNA transcription (GO:1902895)positive regulation of miRNA transcription (GO:1902895)positive regulation of miRNA transcription (GO:1902895)positive regulation of microglial cell mediated cytotoxicity (GO:1904151)positive regulation of microglial cell mediated cytotoxicity (GO:1904151)positive regulation of myeloid dendritic cell chemotaxis (GO:2000529)positive regulation of p38MAPK cascade (GO:1900745)positive regulation of p38MAPK cascade (GO:1900745)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)pro-T cell differentiation (GO:0002572)pro-T cell differentiation (GO:0002572)protein binding (GO:0005515)protein sequestering activity (GO:0140311)protein sequestering activity (GO:0140311)regulation of DNA-templated transcription (GO:0006355)regulation of DNA-templated transcription (GO:0006355)regulation of erythrocyte differentiation (GO:0045646)regulation of myeloid progenitor cell differentiation (GO:1905453)regulation of myeloid progenitor cell differentiation (GO:1905453)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)response to ethanol (GO:0045471)sequence-specific DNA binding (GO:0043565)sequence-specific DNA binding (GO:0043565)transcription cis-regulatory region binding (GO:0000976)transcription cis-regulatory region binding (GO:0000976)transcription initiation-coupled chromatin remodeling (GO:0045815)transcription initiation-coupled chromatin remodeling (GO:0045815)transcription initiation-coupled chromatin remodeling (GO:0045815)transcription regulator complex (GO:0005667)transforming growth factor beta receptor signaling pathway (GO:0007179)
Expression (TPM)
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