ZBTB46

zinc finger and BTB domain containing 46 | BZEL, FLJ13502, RINZF, BTBD4, ZNF340

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-8 DE-8.4

Biological processes 24 terms

DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)chromatin (GO:0000785)chromatin (GO:0000785)chromatin (GO:0000785)chromosome (GO:0005694)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleus (GO:0005634)nucleus (GO:0005634)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)regulatory T cell differentiation (GO:0045066)regulatory T cell differentiation (GO:0045066)tolerance induction in gut-associated lymphoid tissue (GO:0002394)tolerance induction in gut-associated lymphoid tissue (GO:0002394)transcription cis-regulatory region binding (GO:0000976)transcription cis-regulatory region binding (GO:0000976)transcription coregulator activity (GO:0003712)transcription coregulator activity (GO:0003712)

Expression (TPM)

TFs regulating ZBTB46 0 TFs

Transcription factors with Perturb-seq knockdown data for ZBTB46. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZBTB46 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ZBTB46

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZBTB46, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr20:63,537,759–63,538,455	293.2 kb	Distal (>10kb) Multiome	823
chr20:63,552,551–63,554,733	277.7 kb	Distal (>10kb) Multiome	544
chr20:63,573,969–63,574,596	257.0 kb	Distal (>10kb) Multiome	551
chr20:63,626,480–63,627,647	204.2 kb	Distal (>10kb) Multiome	982
chr20:63,641,266–63,642,913	189.2 kb	Distal (>10kb) Multiome	691
chr20:63,652,233–63,654,166	177.7 kb	Distal (>10kb) Multiome	1011
chr20:63,657,813–63,658,939	172.8 kb	Distal (>10kb) Multiome	1055
chr20:63,696,254–63,697,070	134.7 kb	Distal (>10kb) Multiome	458
chr20:63,707,489–63,708,488	123.3 kb	Distal (>10kb) Multiome	1008
chr20:63,737,573–63,741,470	91.6 kb	Distal (>10kb) Multiome	1098
chr20:63,775,216–63,775,997	55.8 kb	Distal (>10kb) Multiome	257
chr20:63,830,341–63,832,721	34 bp	At TSS Multiome	628
chr20:63,835,018–63,835,431	3.8 kb	Proximal (<10kb)	324
chr20:63,846,273–63,846,790	15.2 kb	Distal (>10kb) Multiome	487
chr20:63,864,234–63,865,991	33.9 kb	Distal (>10kb) Multiome	1158
chr20:63,894,341–63,895,764	63.8 kb	Distal (>10kb) Multiome	791
chr20:63,938,191–63,939,815	107.4 kb	Distal (>10kb) Multiome	287
chr20:63,939,918–63,942,008	110.3 kb	Distal (>10kb) Multiome	496
chr20:63,955,375–63,956,875	125.1 kb	Distal (>10kb) Multiome	1107
chr20:63,956,976–63,958,127	126.4 kb	Distal (>10kb) Multiome	709
chr20:63,969,149–63,970,667	138.7 kb	Distal (>10kb) Multiome	764
chr20:63,973,660–63,974,150	142.7 kb	Distal (>10kb) Multiome	767
chr20:63,980,541–63,981,488	149.9 kb	Distal (>10kb) Multiome	986
chr20:64,030,226–64,031,221	199.5 kb	Distal (>10kb) Multiome	159
chr20:64,038,338–64,039,469	207.9 kb	Distal (>10kb) Multiome	628
chr20:64,047,989–64,049,987	218.2 kb	Distal (>10kb) Multiome	541
chr20:64,053,902–64,054,682	223.0 kb	Distal (>10kb) Multiome	609
chr20:64,057,481–64,058,099	226.6 kb	Distal (>10kb) Multiome	659
chr20:64,062,561–64,063,881	231.8 kb	Distal (>10kb) Multiome	991
chr20:64,079,311–64,080,472	248.7 kb	Distal (>10kb) Multiome	688
chr20:64,083,392–64,084,408	252.4 kb	Distal (>10kb) Multiome	591
chr20:64,101,897–64,102,924	271.1 kb	Distal (>10kb) Multiome	457

Genome Browser

Genomic view of the ZBTB46 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.