This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for BCL2L2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BCL2L2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BCL2L2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:23,006,674–23,007,583 | 299.7 kb | Distal (>10kb) Multiome | 1097 | |
| chr14:23,020,642–23,021,291 | 285.9 kb | Distal (>10kb) Multiome | 148 | |
| chr14:23,101,326–23,101,861 | 205.2 kb | Distal (>10kb) Multiome | 83 | |
| chr14:23,182,495–23,182,942 | 124.1 kb | Distal (>10kb) Multiome | 139 | |
| chr14:23,237,732–23,238,192 | 68.9 kb | Distal (>10kb) Multiome | 536 | |
| chr14:23,285,641–23,286,830 | 20.6 kb | Distal (>10kb) Multiome | 962 | |
| chr14:23,300,944–23,303,002 | 5.2 kb | Proximal (<10kb) Multiome | 1096 | |
| chr14:23,306,324–23,307,321 | 68 bp | At TSS Multiome | 871 | |
| chr14:23,320,558–23,322,196 | 14.4 kb | Distal (>10kb) Multiome | 1090 | |
| chr14:23,351,817–23,353,063 | 46.0 kb | Distal (>10kb) Multiome | 403 | |
| chr14:23,364,202–23,367,105 | 59.6 kb | Distal (>10kb) Multiome | 353 | |
| chr14:23,468,966–23,469,987 | 162.6 kb | Distal (>10kb) Multiome | 955 | |
| chr14:23,493,984–23,494,589 | 187.5 kb | Distal (>10kb) Multiome | 131 | |
| chr14:23,544,507–23,545,444 | 237.9 kb | Distal (>10kb) Multiome | 308 | |
| chr14:23,550,782–23,552,258 | 244.9 kb | Distal (>10kb) Multiome | 826 | |
| chr14:23,555,640–23,556,485 | 249.2 kb | Distal (>10kb) Multiome | 983 | |
| chr14:23,567,065–23,567,976 | 260.8 kb | Distal (>10kb) Multiome | 855 | |
| chr14:23,575,776–23,576,501 | 269.4 kb | Distal (>10kb) Multiome | 163 | |
| chr14:23,589,018–23,589,481 | 282.3 kb | Distal (>10kb) Multiome | 770 |
Genomic view of the BCL2L2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.